Publications by authors named "Jose de Maria de Albuquerque de Melo Junior"
Aims: To test for the possible antinociceptive effect of nifedipine in rodent models of acute and chronic neuropathic orofacial pain and the possible involvement of TRP- and NMDA-related processes in this effect.
Methods: Acute nociceptive behavior was induced by administering formalin, cinnamaldehyde, glutamate, capsaicin, or acidified saline to the upper lip or hypertonic saline to the cornea of Swiss mice. Acute nociceptive behavior was also induced by formalin injected into the TMJ or mustard oil injected into the masseter muscle of Wistar rats.
Article Synopsis
- * Eucalyptol significantly reduced pain responses in various tests involving acute and chronic pain models, with effects showing sensitivity to TRPV1 receptor involvement.
- * The study suggests that eucalyptol could be a useful clinical treatment for orofacial pain by acting as an antagonist to TRPV1 channels, without affecting locomotor activity.