Electrochemical and CD-spectroelectrochemical studies of the interaction between BSA and the complex [Cu(Bztpen)], (Bztpen = (N-benzyl-N, N', N'-tris (pyridin-2-ylmethyl) ethylenediamine).

In this work we report the electrochemical, spectroscopical and spectro-electrochemical studies of a model complex [Cu(Bztpen)], (Bztpen = (N-benzyl-N,N',N'-tris(pyridin-2-ylmethyl)ethylenediamine) in order to propose a methodology to evaluate the interaction of potential metal based anticancer agents during electron transfer processes, with transport proteins such as Bovine Serum Albumin (BSA). It was possible to establish a reversible electron transfer [Cu(Bztpen)] +1e → [Cu(Bztpen)] and a weak interaction energy between BSA and [Cu(Bztpen)] and [Cu(Bztpen)] species, with no adsorption of protein over the electrode surface. Circular Dichroism (CD) Spectroelectrochemistry, not reported before, reveals no significant changes in BSA structure during the electron transfer [Cu(Bztpen)] + 1e → [Cu(Bztpen)].