Publications by authors named "Jose de Jesus Garcia-Trejo"
Mitochondrial proteomic profile of complex IV deficiency fibroblasts: rearrangement of oxidative phosphorylation complex/supercomplex and other metabolic pathways.
Bol Med Hosp Infant Mex
May 2019
Article Synopsis
- Mitochondriopathies are complex diseases impacting the oxidative phosphorylation system, with skin fibroblasts used to study their mechanisms and functions.
- Fibroblasts with complex IV defects confirmed the disease phenotype and revealed significant issues in the OXPHOS system, particularly in protein complexes that form supercomplexes.
- The findings highlight that these mitochondriopathies not only affect energy production but also disrupt DNA processes and metabolic pathways, which can improve disease classification and treatment approaches.
In this work it is emphasized the presence of the fibrinolitico system in different physiological mechanisms, specially in the antithrombotic regulation of the hemostasis. It is described: the mechanism of activation of plasminogen by their activators as much on the fibrin as in the cells surface; the inhibition of the activators in different metabolic alterations.
View Article and Find Full Text PDFThe heart is the first organ to form and function in the embryo, and all subsequent events in the life of the organism depend on the heart's ability to match its output with the organism's demands for oxygen and nutrients. Abnormalities in heart formation, the most common form of human birth defects, afflict nearly 1% of newborns, and their frequency in spontaneously aborted pregnancies is estimated to be tenfold higher. With the completion of the sequencing of the human genome, molecular genetic efforts directed at finding genes for monogenic traits have accelerated dramatically.
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