Publications by authors named "Jose W Vasconcelos"
Atypical fractures are well elucidated when they occur in the femur and are related to the use of bisphosphonates. Prolonged therapy with this drug leads to excessive suppression of bone remodeling, which makes the bone more brittle. In general, they are caused by minimal trauma or are atraumatic.
View Article and Find Full Text PDFStrontium ranelate (SrRan) has the potential to interfere in the progression of osteoarthritis (OA), multifactorial disease associated with mechanical problems and articular inflammatory changes. This study aimed to test the effects of prophylactic and therapeutic use of SrRan on clinical parameters of pain, the inflammatory process, and degradation of the articular cartilage. This was an experimental study, using a model of knee OA induced by intra-articular injection of monoiodoacetate.
View Article and Find Full Text PDFArticle Synopsis
- The study compared the effects of Actonel(®) plus calcium/vitamin D versus calcium/vitamin D alone on bone mineral density in postmenopausal women with Colles fractures.
- The ACD group showed a smaller loss in bone mineral density (20.8%) compared to the CD group (32.8%), but this difference was not statistically significant.
- Both treatment groups experienced similar times for fracture healing, indicating that while Actonel may help reduce BMD loss, it doesn't significantly impact fracture recovery time.
Objective: To mid-term evaluate patients who were submitted to total knee arthroplasty without patellar resurfacing.
Methods: It was realized a retrospective cross-sectional study of patients who were submitted to total knee arthroplasty without patellar resurfacing. In all patients clinical examination was done based on the protocol of the Knee Society Scoring System, which assessed pain, range of motion, stability, contraction, knee alignment and function, and radiological evaluation.
Objective: Evaluate the effects of simvastatin in the process of fracture healing in rat tibia.
Methods: Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days post-fracture (7th, 14th and 28th day) to assess bone healing. In GE was administered by gavage a solution of simvastatin to the sacrifice.
Background And Objectives: Total knee arthroplasty (TKA) is associated with significant postoperative pain. Many intra-articular (IA) agents have been used for postoperative analgesia with inconsistent outcomes. Ketamine's enantiomer S(+), S(+)- ketamine, was recently introduced commercially, with higher analgesic potency and less side effects than the racemic form.
View Article and Find Full Text PDFBackground And Objectives: Although the efficacy of intraarticular (IA) morphine is still controversial, it has been shown that higher doses promote better results and consequently decrease postoperative analgesic consumption, characterizing a dose-dependent peripheral action. A controlled, randomized, double-blind study was undertaken to evaluate the efficacy of the intra-articular administration of 10 mg of morphine in patients undergoing total knee arthroplasty.
Methods: Fifty patients undergoing total knee arthroplasty were randomly divided into two groups: the treatment group received 10 mg (1 mL) of intra-articular morphine diluted in 19 mL of NS, while the control group received the intra-articular administration of 20 mL of NS, both after closure of the capsule at the end of the surgery.