Publications by authors named "Jose W L Tavares-Junior"
Background: Olfactory dysfunction (OD) represents a frequent manifestation of the coronavirus disease 2019 (COVID-19). Apolipoprotein E (APOE) is a protein that interacts with the angiotensin-converting enzyme receptor, essential for viral entry into the cell. Previous publications have suggested a possible role of APOE in COVID-19 severity.
View Article and Find Full Text PDFThe link between long COVID-19 and brain/cognitive impairments is concerning and may foster a worrisome worldwide emergence of novel cases of neurodegenerative diseases with aging. This review aims to update the knowledge, crosstalk, and possible intersections between the Post-COVID Syndrome (PCS) and Alzheimer's disease (AD). References included in this review were obtained from PubMed searches conducted between October 2023 and November 2023.
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- A recent study explored the relationship between ε4 gene polymorphism, cognitive deficits, and COVID-19 in outpatient patients experiencing neurological symptoms for over three months post-infection.
- The research included 219 confirmed COVID-19 patients, finding that a significant portion reported memory issues, though only a small percentage had these concerns verified through cognitive screening tests.
- Results indicated a higher prevalence of the ε4 allele in patients with cognitive decline compared to those without, and the association remained strong even after considering sleep disorders and anxiety symptoms.
Erythema multiforme (EM), an immune-mediated skin condition, can occur after infection or following the use of medications. In this study, we describe a patient who developed EM after nirmatrelvir/ritonavir administration. An 81-year-old woman presented with fever and dyspnea.
View Article and Find Full Text PDFThe Cogan's sign is indicative of myasthenia gravis. This is the first report of neurological signs in a patient with post-COVID-19 vaccine-associated myasthenia gravis in Brazil. In this case, a previously healthy 68-year-old woman presented with proximal limb weakness, left ptosis, and diplopia 1 month after receiving her fourth dose of the COVID-19 vaccine.
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- * Diagnosis of CJD involves assessing clinical symptoms alongside brain imaging, electroencephalogram results, and cerebrospinal fluid analysis for specific markers.
- * A case study of a 53-year-old patient in Fortaleza, Brazil, confirmed a probable diagnosis of sporadic CJD using tests for 14-3-3 protein and RT QUIC analysis, ruling out other similar conditions.
Introduction: Long-onset COVID syndrome has been described in patients with COVID-19 infection with persistence of symptoms or development of sequelae beyond 4 weeks after the onset of acute symptoms, a medium- and long-term consequence of COVID-19. This syndrome can affect up to 32% of affected individuals, with symptoms of fatigue, dyspnea, chest pain, cognitive disorders, insomnia, and psychiatric disorders. The present study aimed to characterize and evaluate the prevalence of sleep symptoms in patients with long COVID syndrome.
View Article and Find Full Text PDFIntroduction: Few studies have objectively evaluated cognitive deficits after the acute phase of COVID-19 disease. Moreover, the role of apolipoprotein E (APOE) genotypes in cognitive decline in patients with COVID-19 has not been evaluated yet.
Methods: This cross-sectional study was conducted in confirmed cases of COVID-19 patients with neurological symptoms that persisted for more than 3 months from the onset.
Introduction: COVID-19 has a wide range of clinical manifestations. Neurological manifestations in COVID-19 patients were demonstrated during the pandemic, including cognitive impairment. This study aimed to determine any relationship between COVID-19 and cognitive complaints, such as dementia, mild cognitive impairment (MCI), or subjective cognitive decline (SCD).
View Article and Find Full Text PDFIntroduction: This article aims to describe a patient with Parinaud syndrome due to neurotuberculosis confirmed by cerebrospinal fluid analysis.
Case Report: Initially, patient sought medical care, performed a chest x-ray and later a chest CT scan, with a probable diagnosis of miliary tuberculosis. In addition, she presented binocular diplopia worse at right lateral gaze, paresis of vertical gaze, light near-dissociation and convergent retraction nystagmus and presence of mycobacterium tuberculosis on PCR Xpert MTB/RIF.
Article Synopsis
- Headache is a common symptom in COVID-19, affecting 6.5% to 34% of patients, but previous studies often included unverified cases or focused on severe cases.
- The study analyzed 24 laboratory-confirmed COVID-19 patients who reported headaches, revealing that the average age was 53.8 years and most had no prior history of headaches.
- The headaches were mainly bifrontal or holistic, of a pressure quality, typically began early in illness, and worsened with physical activity, but no unique characteristics were found to distinguish them from other headache causes.
Cognitive assessment of older adults who are either illiterate or with low levels of education is particularly challenging because several battery tasks require a certain educational background. Early detection of mild cognitive impairment (MCI) in the elderly using validated screening tools is of great importance since this population group could benefit from new drugs that are being investigated for the treatment of dementias. Cutoff scores for psychometric properties of cognitive tests are not well established among adults with low levels of education.
View Article and Find Full Text PDFBackground: Corticobasal syndrome (CBS) is a complex neurodegenerative disorder associated with parkinsonism and alien limb syndrome. Dressing and ideomotor apraxia were reportedly responsive to amantadine.
Case Report: A 79-year-old female was referred for evaluation of right hemiparesis.