Role of thrombospondin-1 in repair of penetrating corneal wounds.

Purpose: Thrombospondin-1 (THBS1) has been suggested as a corneal wound-healing modulator. Therefore, we compromised the integrity of the cornea to elucidate the role of THBS1.

Methods: Full-thickness penetrating corneal incisions (1.

αVβ6 integrin promotes corneal wound healing.

Purpose: To appreciate the role of the integrin αvβ6 in corneal wound repair, corneal debridement and keratectomy in β6 knockout (β6(-/-)) mice were examined.

Methods: Either a 2-mm debridement or keratectomy was made in 129SVE wild type mice (WT) and β6(-/-) mice and allowed to heal for up to 4 months. The pattern of corneal restoration was studied "in vivo" by slit lamp and in tissue sections by means of both light and electron microscopy.

Presence of mitomycin-C in the anterior chamber after photorefractive keratectomy.

Purpose: To assess the presence of mitomycin-C (MMC) in hen aqueous humor after photorefractive keratectomy (PRK).

Setting: Instituto Universitario de Oftalmobiología Aplicada, Faculty of Medicine, University of Valladolid, and Department of Analytical Chemistry, Faculty of Sciences, University of Valladolid, Valladolid, Spain.

Methods: Mitomycin-C 0.

Experimental model of laser in situ keratomileusis in hens.

Purpose: To develop an experimental animal model of laser in situ keratomileusis (LASIK) in hens.

Methods: One hundred adult hens underwent a 60-microm corneal flap followed by -4 diopter excimer laser ablation. Surgical technique, clinical course, and pathology correlations are presented.