Diphenyl ditelluride (PhTe), an organotelluric compound with pharmacological and toxicological attributes, has shown promise in microorganism studies. , an alternative animal model, is gaining popularity for novel antimicrobial research due to its cost-effectiveness, versatility, and similarity to vertebrate models. Given the rising antibiotic resistance, particularly in (), the exploration of novel antimicrobials is of utmost importance.
View Article and Find Full Text PDFSleep is a fundamental state for maintaining the organism homeostasis. Disruptions in sleep patterns predispose to the appearance of memory impairments and mental disorders, including depression. Recent pre-clinical studies have highlighted the antidepressant-like properties of the synthetic compound 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1).
View Article and Find Full Text PDFPharmacol Biochem Behav
November 2023
Anxiety disorders, characterized by high prevalence rates, cause psychiatric disabilities and are related to impairments in serotoninergic system function. Frequent anxiety recurrence, resistance, and drug adverse effects have driven searches for new therapies. We initially evaluated the anxiolytic-like activity of 3-selanyl-benzo[b]furan compounds (SeBZF1-5) (50 mg/kg, i.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
November 2023
Prog Neuropsychopharmacol Biol Psychiatry
July 2023
Synthetic glucocorticoid administration has been reported to play a role in depression and cognitive decline. The present study investigated the 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) effects against the depressive-like behavior, memory impairment, and neurochemical alterations caused by acute dexamethasone administration in female Swiss mice. A dexamethasone dose-response curve (0.
View Article and Find Full Text PDFThe present study investigated the antidepressant-like potential of a functionalized 3-selanyl benzo[]furan (SeBZF) in male Swiss mice. To evaluate possible antidepressant-like actions, the compounds SeBZF (50 mg/kg, intragastric, i.g.
View Article and Find Full Text PDFPsychopharmacology (Berl)
October 2021
Rationale: Depression is a psychiatric disorder that constitutes one of the leading causes of disability worldwide. 2-Phenyl-3-(phenylselanyl)benzofuran (SeBZF1) has been studied as a potential antidepressant drug, but its pharmacological action needs more investigation.
Objectives And Methods: Our aim was to extend information about the antidepressant-like action of SeBZF1 using the mouse tail suspension test (TST).
A series of selenylated-oxadiazoles were prepared and their interaction with DNA was investigated. The photophysical studies showed that all the selenylated compounds presented absorption between 270 and 329 nm, assigned to combined n→π* and π→π* transitions, and an intense blue emission (325-380 nm) with quantum yield in the range of = 0.1-0.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
August 2020
Monoaminergic and oxidative dysfunctions have been reported to play a role in depression. The present study investigated the antioxidant potential as well as the antidepressant-like action of 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) in male Swiss mice. Time and dose-response curves were analyzed with the forced swim (FST) and tail suspension (TST) tests, in which SeBZF1 elicited antidepressant-like effects.
View Article and Find Full Text PDFA simple and practical protocol for the synthesis of 3-selanyl-benzo[]furans mediated by the SelectFluor® reagent was developed. This novel methodology provided a greener alternative to generate 3-substituted-benzo[]furans a metal-free procedure under mild conditions. The intramolecular cyclization reaction was carried out employing an electrophilic selenium species generated through the reaction between SelectFluor® and organic diselenides.
View Article and Find Full Text PDFOur previous study demonstrated that 2-phenylethynyl-butyltellurium (PEBT), an organotellurium compound, enhances memory in mice. In this study, the effects of PEBT on cognitive impairment induced by Aβ25-35 were assessed by Morris water maze and step-down inhibitory avoidance tasks. Mice received a single intracerebroventricular injection of Aβ25-35 (3 nmol/3 μl/per site) and a daily oral administration of PEBT (1 mg/kg, for 10 days).
View Article and Find Full Text PDFThe present study was conducted to evaluate the effect of 2-phenylethynyl-butyltellurium (PEBT), an organotellurium compound, at doses of 5 and 10 mg/kg on memory, employing the step-down inhibitory avoidance task in mice. Moreover, the involvement of glutamate uptake and release in cerebral cortex and hippocampus of mice was investigated. A single oral administration (p.
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