Publications by authors named "Jose Santos-Borbujo"

Introduction: The need for effective methods of detection and treatment in the early stages of autism spectrum disorders is something that is currently accepted both by professional societies and by the healthcare authorities alike. Up-to-date comprehensive information about the screening procedures and early care techniques for children with autism spectrum disorders would make it easier to implement better detection devices as well as easing the job of counselling families and professionals about care and intervention at early ages in children.

Development: This study offers an updated review of the procedures for early detection and early care in autism, while reflecting the most relevant aspects that can be deduced from the experiments and studies conducted to date.

View Article and Find Full Text PDF

Introduction: To be able to treat prolonged epileptic crises practical, safe and effective rescue medication is needed. Today, the standard treatment in community healthcare is rectal diazepam. The introduction of a buccal solution of midazolam opens up a new perspective in their treatment.

View Article and Find Full Text PDF

Early detection and treatment have been shown to be effective in reducing disability severity caused by Autistic Spectrum Disorders (ASDs). As Spanish pediatricians have no detection tool, the Modified Checklist for Autism in Toddlers (M-CHAT) was first translated into and culturally adapted to Spanish. Validity and reliability studies were carried out in two different geographical areas of Spain, where M-CHAT was administered to two different samples, namely: 2,480 high- and low-risk children; and 2,055 low-risk children.

View Article and Find Full Text PDF
Article Synopsis
  • - This study created a pharmacokinetic model to analyze how lamotrigine (LTG) behaves in the bodies of Spanish and German epilepsy patients based on data from 600 individuals and 1699 plasma drug samples.
  • - The final model revealed that factors like total body weight and the presence of other medications (like valproic acid or carbamazepine) significantly affect LTG clearance rates, with comedication modifying the average clearance by over 40%.
  • - While this model can help doctors set initial dosages, it still shows around 30% variability in individual responses, highlighting the importance of monitoring LTG plasma levels for accurate dosage adjustments.
View Article and Find Full Text PDF