Publications by authors named "Jose S Reyes"
Background: The incidence of sporadic colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing in the United States (U.S.) and Puerto Rico.
View Article and Find Full Text PDFObjective: Colorectal cancer is the leading cause of cancer death in Puerto Rico and third among Hispanics in the USA. Up to 2-4% of colorectal cancer cases are a result of Lynch syndrome (LS), a hereditary cancer syndrome caused by a germline mutation in at least one of the DNA mismatch repair genes. The objective of this study was to determine the prevalence of LS in colorectal tumors during the first 15-months after the implementation of universal tumor-based screening for LS in Puerto Rico.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer (CRC) is the leading cause of cancer deaths in Puerto Rico, with rising incidence and mortality rates, particularly compared to US Hispanics and second only to African Americans.
- A study assessed the genetic ancestry of 406 Puerto Rican CRC cases using a panel of 105 ancestry informative markers, revealing a population composition of 61% European, 21% African, and 18% Amerindian.
- Although there was no overall association between genetic ancestry and CRC risk, African ancestry was linked to a higher risk of rectal tumors, indicating a need for further research on its role in CRC development.
Objective: The purpose of this study is to determine the prevalence rate of estrogen and progesterone receptors and HER 2/neu in the breast cancer biopsies analyzed in the Laboratory of Immunohistochemistry of the University of Puerto Rico School of Medicine in the year 2000. This data may serve as a reference point for future studies of the epidemiological aspects of breast cancer among women living in Puerto Rico.
Background: Determination of estrogen receptor (ER) and progesterone receptor (PR) on biopsy specimens of breast carcinoma prior to treatment is standard practice in the management of breast carcinoma.