Computational Evaluation of Fusarium nygamai Compounds as AcrD Efflux Pump Protein Inhibitors of Salmonella Typhimurium.

In Salmonella Typhimurium, efflux pump proteins, such as AcrD actively expel drugs and hazardous chemicals from bacterial cells, resulting in treatment failure and the emergence of antibiotic-resistant variants. Focusing on AcrD may lead to the development of novel antimicrobials against multidrug-resistant bacteria. However, challenges persist in achieving high selectivity, low toxicity, and effective bacterial penetration.

The pangenome analysis of the environmental source Salmonella enterica highlights a diverse accessory genome and a distinct serotype clustering.

Salmonella remains the leading cause of foodborne infections globally. Environmental reservoirs, particularly aquatic bodies, serve as conduits for the fecal-oral transmission of this pathogen. While the gastrointestinal tract is traditionally considered the primary habitat of Salmonella, mounting evidence suggests the bacterium's capacity for survival in external environments.

Immunoinformatic approach for multi-epitope vaccine design against Staphylococcus aureus based on hemolysin proteins.

Staphylococcus aureus is a common bacterium that causes a variety of infections in humans. This microorganism produces several virulence factors, including hemolysins, which contribute to its disease-causing ability. The treatment of S.

Genomic insights of associated with bovine mastitis in a high livestock activity region of Mexico.

Importance: Bovine mastitis, predominantly associated with gram-positive , poses a significant threat to dairy cows, leading to a decline in milk quality and volume with substantial economic implications.

Objective: This study investigated the incidence, virulence, and antibiotic resistance of associated with mastitis in dairy cows.

Methods: Fifty milk-productive cows underwent a subclinical mastitis diagnosis, and the strains were isolated.

Genomic characteristics of Montevideo and Pomona: impact of isolation source on antibiotic resistance, virulence and metabolic capacity.

is known for its disease-causing serotypes, including Montevideo and Pomona. These serotypes have been found in various environments, including river water, sediments, food, and animals. However, the global spread of these serotypes has increased, leading to many reported infections and outbreaks.

Prevalence and Genomic Diversity of Recovered from River Water in a Major Agricultural Region in Northwestern Mexico.

is a leading cause of human gastrointestinal disease worldwide. Given that is persistent in aquatic environments, this study examined the prevalence, levels and genotypic diversity of isolates recovered from major rivers in an important agricultural region in northwestern Mexico. During a 13-month period, a total of 143 river water samples were collected and subjected to size-exclusion ultrafiltration, followed by enrichment, and selective media for isolation and quantitation.

Vibrios from the Norwegian marine environment: Characterization of associated antibiotic resistance and virulence genes.

A total of 116 Vibrio isolates comprising V. alginolyticus (n = 53), V. metschnikovii (n = 38), V.