The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.

Background & Aims: Helicobacter pylori eradication and endoscopic surveillance of gastric precancerous lesions are strategies to reduce gastric cancer (GC) risk. To our knowledge, this study is the longest prospective cohort of an H pylori eradication trial in a Hispanic population.

Methods: A total of 800 adults with precancerous lesions were randomized to anti-H pylori treatment or placebo.

Duodenal microbiome in patients with or without Helicobacter pylori infection.

Background: Intestinal microbiota are recognized as an organ with important physiological functions whose alterations have been associated with common diseases including inflammatory intestinal conditions, malnutrition, type-2 diabetes, and cardiovascular diseases. The composition and function of the microbiota in the distal part of the intestine has been mainly described, while there is limited information on the small intestine microbiota. The objective of the present study was to describe the duodenal microbiome in individuals with dyspepsia in the presence or absence of Helicobacter pylori gastric infection.

Dynamics of infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial.

Objective: To evaluate the long-term effect of cumulative time exposed to infection on the progression of gastric lesions.

Design: 795 adults with precancerous gastric lesions were randomised to receive anti- treatment at baseline. Gastric biopsies were obtained at baseline and at 3, 6, 12 and 16 years.

[Source of variation in the diagnosis of Helicobacter pylori-associated multifocal atrophic gastritis.].

Introduction: Multiple sampling from different sites of the stomach as well as the number of fragments of gastric mucosa available for histopathologic evaluation are important sources of variation when classifying and grading chronic gastritis.

Objective: To estimate the sensitivity of the number of fragments of gastric mucosa necessary to establish the diagnosis of atrophic gastritis with intestinal metaplasia, gastric dysplasia and infection. In addition, this study will attempt to assess the intra-observer variability in the classification of these premalignant gastric lesions.