Publications by authors named "Jose Ramon Ortiz-Gomez"
Purpose: Postoperative delirium (POD) is a common and serious neuropsychiatric syndrome that leads to higher morbidity and mortality. We investigated the association between serum C-reactive protein (CRP) and the occurrence of POD in older hip fracture patients, and whether CRP predicted POD better than a clinical model.
Methods: Patients aged ≥ 75 years admitted for surgical repair of an acute hip fracture were recruited.
Objective: Delirium is a serious neuropsychiatric syndrome frequently occurring in hospitalized older adults, for which pharmacological treatments have shown limited effectiveness. Multicomponent physical exercise programs have demonstrated functional benefits; however, the impact of exercise on the course of delirium remains unexplored. The aim of this study was to investigate the effect of an individualized, multicomponent exercise intervention on the evolution of delirium and patient outcomes.
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- Postoperative delirium (POD) is a frequent issue in elderly patients after hip fracture surgery, leading to adverse outcomes, and this study aimed to find links between biomarkers and POD development.
- Sixty patients were observed for signs of POD after spinal anesthesia, using daily assessments to classify them into POD and non-POD groups, with blood and cerebrospinal fluid (CSF) samples collected for analysis.
- Results showed that 35% of patients developed POD, with a notable correlation between lower levels of the cytokine CXCL9 in both serum and CSF and the incidence of POD, suggesting that these biomarkers could help create predictive models for delirium.
Reducing by 50% the incidence of maternal hypotension during elective caesarean delivery under spinal anesthesia: Effect of prophylactic ondansetron and/or continuous infusion of phenylephrine - a double-blind, randomized, placebo controlled trial.
Saudi J Anaesth
January 2017
Background: Prophylactic administrations of ondansetron or phenylephrine have been reported to provide a protective effect against hypotension in women undergoing cesarean delivery under spinal anesthesia (SA). The main hypothesis is that ondansetron improves the hemodynamic response, especially combined with phenylephrine infusion.
Methods: This prospective, double-blind, randomized, placebo-controlled study included 265 healthy pregnant women scheduled for elective cesarean delivery under SA.