Publications by authors named "Jose R Villagrasa"
Beneficial effect of temporary methotrexate interruption on B and T cell responses upon SARS-CoV-2 vaccination in patients with rheumatoid arthritis or psoriatic arthritis.
NPJ Vaccines
January 2024
Article Synopsis
- A study evaluated the immune response of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients to COVID-19 vaccines after stopping methotrexate (MTX) treatment for 1 or 2 weeks compared to those who continued MTX.
- Patients who paused MTX showed higher levels of antibodies and a stronger T-cell response, particularly in the group that withdrew for 2 weeks.
- Importantly, stopping MTX did not lead to increased flare-ups of RA or PsA, suggesting that a temporary withdrawal could enhance vaccine effectiveness without risking disease stability.
Introduction: To compare Engerix-B and Fendrix hepatitis B virus for primo vaccination in inflammatory bowel disease (IBD).
Methods: Patients with IBD were randomized 1:1 to receive Engerix-B double dose or Fendrix single dose at months 0, 1, 2, and 6. Anti-HBs titers were measured 2 months after the third and fourth doses.
Background: Clinically significant hepatitis B (HB) virus infection has been documented among immunocompromised patients who do not maintain anti-hepatitis surface antigen (anti-HBs) concentrations ≥ 10 IU/L after an adequate response to the vaccine. The aims of the study were to understand the kinetics of anti-HBs titers over time in patients with inflammatory bowel disease (IBD) who initially responded to vaccination and to identify factors predictive of losing protective anti-HBs titers.
Methods: Patients with IBD with a response (anti-HBs > 10 IU/L at 1-3 months) to HB virus vaccination were prospectively included.
Objectives: To assess the appropriateness of antibiotic prescription for urinary tract infections in several hospital emergency services and to evaluate the variability of antibiotic prescription among these services.
Methods: A cross-sectional study was carried out in the emergency services of 10 hospitals from different Spanish regions. The sample was composed of patients diagnosed with acute urinary infection, aged> or =14 years.