Publications by authors named "Jose R Quejada"
Article Synopsis
- Some mutations in the Ca1.2 calcium channel gene lead to Timothy syndrome, a severe form of long QT syndrome, with no current effective treatments.
- Targeting sigma non-opioid intracellular receptor 1 (SIGMAR1) can restore heart function in heart cells derived from patients with Timothy syndrome and other types of long QT syndrome.
- The FDA-approved cough suppressant dextromethorphan acts as a SIGMAR1 agonist, improving cardiac function in Timothy syndrome models and suggesting a new therapeutic avenue for related inherited arrhythmias.
Lactate metabolism has been shown to have increasingly important implications in cellular functions as well as in the development and pathophysiology of disease. The various roles as a signaling molecule and metabolite have led to interest in establishing a new method to detect lactate changes in live cells. Here we report our development of a genetically encoded metabolic indicator specifically for probing lactate (GEM-IL) based on superfolder fluorescent proteins and mutagenesis.
View Article and Find Full Text PDFNa1.5 inactivation is necessary for healthy conduction of the cardiac action potential. Genetic mutations of Na1.
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- Researchers developed enhanced optogenetic tools to control transcription in mammalian cells using light signals.
- They optimized the FKF1/GI and CRY2/CIB1 systems, increasing the effectiveness of light-induced transcriptional activation.
- These advancements enable more precise light-based regulation of gene expression, which can be applied in various biological studies.
G protein-coupled receptors (GPCRs) represent ∼25% of current drug targets. Ligand binding to these receptors activates G proteins and arrestins, which are involved in differential signaling pathways. Because functionally selective or biased ligands activate one of these two pathways, they may be superior medications for certain diseases states.
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