Publications by authors named "Jose R Gonzalez-Chavez"

Article Synopsis
  • - Hailey-Hailey disease is an autosomal dominant condition caused by a mutation in the ATP2C1 gene, leading to painful skin blisters and erosions, particularly in folds of the skin.
  • - There is currently no cure for the disease, and treatments mainly focus on managing infections and inflammation, with a recent emphasis on targeting the disease's biochemical pathways.
  • - In a case series involving three patients with severe Hailey-Hailey disease, the use of the biologic drug adalimumab successfully controlled their symptoms and maintained remission.
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Article Synopsis
  • Mevalonate kinase deficiency is a rare genetic disorder caused by mutations in the MVK gene, leading to various autoinflammatory diseases, including hyper-IgD syndrome and mevalonic aciduria.
  • Approximately 300 cases have been documented globally, showcasing its rarity.
  • A 3-year-old girl from Puerto Rico was diagnosed with hyper-IgD syndrome after experiencing fever, joint pain, and skin lesions from an early age; she will be treated with canakinumab following routine vaccinations.
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Background: Although major advances in the understanding of its pathogenesis have been achieved, psoriasis remains an incurable disease. In April 2004, etanercept, an antagonist of TNF-alpha, was approved by the Food and Drug Administration for the treatment of chronic, moderate to severe plaque psoriasis in adults. In this study we intend to document the efficacy and further establish the safety profile of etanercept for the treatment of moderate to severe psoriasis in our population and compare our data to the Leonardi et al study published in 2003.

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