Publications by authors named "Jose Prakash"
Portland cement porous concrete (PCPC) has received immense interest recently due to its environmental aids. Its porous structure helps to reduce the water runoff amount while improving the recharge of groundwater. Earlier studies have concentrated on illustrating and knowing the functional as well as structural properties of PCPC.
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- Curcumin, a key active ingredient from a traditional medicinal plant, was studied for its protective effects against liver damage in rats caused by carbon tetrachloride (CCl₄).
- The research involved creating curcumin nanoparticles (ηCur) that are less than 220 nm in size, using specific polymers for stabilization.
- Results showed that ηCur provided significantly greater liver protection compared to regular curcumin, as observed through behavioral tests, serum analysis, and liver tissue examinations.
Clinical effectiveness of imatinib mesylate in cancer treatment is compromised by its off-target cardiotoxicity. In the present study, we have developed physically stable imatinib mesylate-loaded poly(lactide-co-glycolide) nanoparticles (INPs) that could sustainably release the drug, and studied its efficacy by in vitro anticancer and in vivo cardiotoxicity assays. MTT (methylthiazolyldiphenyl-tetrazolium bromide) assay revealed that INPs are more cytotoxic to MCF-7 breast cancer cells compared to the equivalent concentration of free imatinib mesylate.
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