[Efficacy and safety of high dose (≥8 mg/kg/day) daptomycin].

Introduction: There is a paucity of data regarding efficacy and safety of high dose (>8mg/kg/day) daptomycin.

Material And Methods: This ambispective study included all patients that received ≥8 mg/kg/day of daptomycin and had efficacy and safety data.

Results: Sixty-nine patients were included.

Prevalence of exercise pulmonary arterial hypertension in scleroderma.

Objective: Pulmonary arterial hypertension (PAH) is a complication of scleroderma (systemic sclerosis, SSc); as soon as PAH develops, the patient's prognosis deteriorates rapidly. Early detection of PAH ensures timely treatment. We investigated the prevalence of exercise-induced PAH in a cohort of patients with SSc, and examined the relation between exercise-induced PAH and clinical characteristics and biochemical markers.