Publications by authors named "Jose Paz Ibarra"
Introduction: Endocrine paraneoplastic syndromes (ePNS) are caused by malignant cells that induce hormonal alterations unrelated to the tissue of origin of the neoplasm. The aim of this manuscript is to review the pathophysiology, diagnosis, and treatment of endocrine paraneoplastic syndromes (ePNS).
Areas Covered: We searched the PubMed/Medline, Embase, and Scielo databases, including 96 articles.
Article Synopsis
- Acquired hypophosphatemic osteomalacia (AHO) is a rare bone disorder often caused by phosphaturic tumors that lead to low phosphate levels and poor bone mineralization, with tumor-induced osteomalacia (TIO) being the most common culprit.
- A study reviewed seven cases of AHO in Peruvian patients between 1999 and 2023, revealing significant diagnostic challenges and varying outcomes; some patients improved after tumor removal, while others did not and even faced fatalities.
- The findings highlight the necessity for careful diagnosis and treatment planning, as the elusive nature of tumors makes it particularly difficult to manage AHO in regions like Peru with limited medical resources.
Introduction: Primary hyperparathyroidism (PHPT) during pregnancy is rare, with the commonest cause being parathyroid adenoma. Parathyroid cysts represent 0.5% of parathyroid lesions.
View Article and Find Full Text PDF: Amyloid goiter (AG) is a rare cause of thyroid swelling, characterized by deposits of amyloid protein in the thyroid tissue. It can be associated with primary or secondary amyloidosis. Its prevalence in multinodular goiter cases is 0.
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- Ifosfamide can cause a rare problem called Fanconi syndrome, especially in younger patients who take a lot of it.
- A 16-year-old boy who had cancer got ifosfamide and later experienced serious kidney issues, including high sugar in urine and low potassium levels.
- It's important for doctors to keep an eye on kidney health in patients who take ifosfamide, so they can catch any problems early and improve treatment outcomes.
Effects of aerobic exercise on components of the metabolic syndrome in older adults with type 2 diabetes mellitus: systematic review and meta-analysis.
Rev Peru Med Exp Salud Publica
August 2024
Objective.: To determine the effects of aerobic exercise on the components of the metabolic syndrome in older adult diabetic patients by means of a systematic review with meta-analysis.
Materials And Methods.
Introduction: Methimazole is an antithyroid drug known to cause hematological toxicity, including agranulocytosis and, very rarely, pancytopenia. We herein present a case of a patient with Graves' Disease (GD) who developed methimazole-induced pancytopenia.
Case Report: A 53-year-old Peruvian woman with GD, initially treated with methimazole 20 mg BID, experienced odynophagia, fever, and malaise after 37 days of treatment.
Diagnostic Role of Tomography in Addison's Disease due to Adrenal Tuberculosis: A Case Report.
Endocr Metab Immune Disord Drug Targets
July 2024
Article Synopsis
- Adrenal tuberculosis is a leading cause of primary adrenal insufficiency (PAI) in regions where tuberculosis (TB) is common, as highlighted in a case report that used CT imaging for diagnosis.
- A 37-year-old woman from Peru, who had been exposed to TB, showed signs of adrenal insufficiency; CT scans revealed enlarged adrenals with calcifications, leading to a diagnosis of adrenal TB.
- Despite treatment with prednisone and anti-TB medication resulting in symptom relief, she later died from pneumonia, emphasizing the need for awareness of adrenal TB in TB-endemic areas and the role of CT in diagnosis when biopsies are not possible.
Article Synopsis
- * Risk factors for DTC are varied, including genetic, environmental, and lifestyle elements like age, gender, obesity, and exposure to radiation or pollutants.
- * Advances in DTC management, such as precision medicine and immunotherapy, highlight the need for collaborative research in order to improve future diagnostic and treatment strategies.
Calcitonin-producing Duodenal Neuroendocrine Tumor: A Case Report and Literature Review.
Endocr Metab Immune Disord Drug Targets
June 2024
Introduction: Neuroendocrine tumors [NETs] exhibit a wide range of clinical presentations, including the production of various hormones. Calcitonin, a sensitive marker for medullary thyroid cancer [MTC], is nonspecific and may be elevated in extra-thyroidal NETs.
Case Report: We present the case of a 64-year-old female patient who underwent total thyroidectomy due to a nodule in the isthmus, with a fine-needle aspiration biopsy indicating follicular neoplasia.
Hepatocrinology explores the intricate relationship between liver function and the endocrine system. Chronic liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis disruption. Despite its importance, assessing endocrine issues in cirrhotic patients is frequently neglected.
View Article and Find Full Text PDFImatinib use in the management of a patient with Doege-Potter syndrome.
Endocrinol Diabetes Metab Case Rep
April 2023
Summary: Doege-Potter syndromeis a paraneoplastic syndrome characterized by nonislet cell tumor hypoglycemia due to a solitary fibrous tumor, which produces insulin-like growth factor II. In this report, we present the case of a 67-year-old male with recurrent and refractory hypoglycemia due to DPS successfully treated with imatinib. He initially presented with neuroglycopenic symptoms and dyspnea secondary to a giant tumor in the left hemithorax, which was totally resected.
View Article and Find Full Text PDFIntroduction: Female infertility is defined as the inability to achieve pregnancy following one year of consistent, unprotected sexual intercourse. Among the various endocrine factors contributing to this complex issue, thyroid dysfunction assumes a pivotal and noteworthy role.
Methods: A narrative review, encompassing 134 articles up to 2023, was conducted utilizing the PubMed/Medline, EMBASE, and Scielo databases.
Background: Obesity is a multifactorial chronic disease with a high, increasing worldwide prevalence. Genetic causes account for 7% of the cases in children with extreme obesity.
Data Sources: This narrative review was conducted by searching for papers published in the PubMed/MEDLINE, Embase and SciELO databases and included 161 articles.
Article Synopsis
- Refractory hypothyroidism (RH) is a challenging condition where standard treatment with high doses of levothyroxine (LT4) fails to control thyroid disease.
- A review of 103 articles highlighted various causes of RH, including noncompliance, changes in LT4 brand, and medical issues like lactose intolerance or infections.
- Early identification and addressing the root causes of RH are crucial to avoid excessive LT4 dosing and prevent potential complications like cardiovascular and bone issues.
Article Synopsis
- Infertility in women is identified as the inability to conceive after a year of unprotected sex, with a focus on endocrine-related issues such as hormonal imbalances and conditions like PCOS and thyroid dysfunction.
- A detailed review analyzed 245 articles, discussing the physiological mechanisms of infertility, diagnostic methods that include hormonal studies, and treatment options starting with lifestyle changes before moving to medication.
- Continued research is essential to address the existing knowledge gaps, aiming for personalized treatments that could significantly improve fertility outcomes in the near future.
Article Synopsis
- Thyrolipomatosis is an extremely rare condition characterized by the infiltration of fatty tissue in the thyroid gland, with only about 30 cases documented globally; it can occur alongside malignant neoplasms but never previously reported with tongue cancer.
- A 44-year-old female patient was diagnosed with an infiltrative tongue mass and underwent surgery, revealing thyrolipomatosis in her thyroid along with the need to remove part of her tongue and lymph nodes.
- Despite the initial treatment, the patient experienced a recurrence of squamous cell carcinoma and complications that led to septic shock and her subsequent death, highlighting the potential risks of coexisting benign and malignant conditions in the thyroid and tongue.
This review provides an update on the epidemiology, pathophysiology, symptoms, diagnosis and treatment of neuroendocrine neoplasms (NENs) of the small bowel (SB). These NENs are defined as a group of neoplasms deriving from neuroendocrine cells. NENs are currently the most common primary tumors of the SB, mainly involving the ileum, making the SB the most frequently affected part of the gastrointestinal tract.
View Article and Find Full Text PDFBackground: Thyrotoxic Periodic Paralysis (PPT) is an uncommon complication of hyperthyroidism, it is the most frequent cause of acute flaccid paralysis in adults.
Material And Methods: A retrospective observational study was carried out in 2 reference hospitals of the social security in Lima-Peru, which included 22 patients diagnosed with PPT during the period 2014-2021.
Results: the average age at diagnosis was 35.
Article Synopsis
- * Cardiovascular complications such as high blood pressure, valve issues, and acromegalic cardiomyopathy can arise due to elevated growth hormone and insulin-like growth factor 1 levels, which impact heart and blood vessel function.
- * Proper diagnosis and treatment can be guided by biochemical markers and imaging studies, as lowering growth hormone and insulin-like growth factor 1 levels can enhance cardiovascular health and improve patient outcomes.
Background And Aims: The prevalence and incidence of infertility are increasing worldwide; they are associated with a significant economic and social impact. Infertility is defined as the inability to achieve pregnancy after 12 months or more of regular unprotected sex. In recent times, the male factor has gained importance and currently it contributes to approximately 50% of infertility cases.
View Article and Find Full Text PDFBackground: Adrenal incidentalomas are tumors that are usually detected in imaging studies indicated without suspicion of adrenal disease. Pheochromocytoma is a neuroendocrine tumor that can occur sporadically or associated with genetic syndromes, having been described in 0.1-5% of patients with type 1 neurofibromatosis, which is a progressive multisystemic disease of autosomal dominant inheritance that affects 1 / 2600-3000 individuals .
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