Publications by authors named "Jose Nobre"
Background: Gut microbiota is intrinsically associated with the immune system and can promote or suppress infectious diseases, especially viral infections. This study aims to characterize and compare the microbiota profile of infected patients with SARS-CoV-2 (milder or severe symptoms), non-infected people, and recovered patients. This is a national, transversal, observational, multicenter, and case-control study that analyzed the microbiota of COVID-19 patients with mild or severe symptoms at home, at the hospital, or in the intensive care unit, patients already recovered, and healthy volunteers cohabiting with COVID-19 patients.
View Article and Find Full Text PDFAcute Chagas Disease Caused by TcIV and Transmitted by : Molecular Epidemiological Insights Provided by the First Documented Autochthonous Case in Rondônia, Southwestern Amazonia, Brazil.
Vector Borne Zoonotic Dis
April 2022
Article Synopsis
- - Recurrent outbreaks and isolated cases of Chagas disease (CD) have been noted in the Brazilian Amazon, particularly acute Chagas disease (ACD) prevalent in regions like Pará and Amazonas, with a specific case described in Rondônia for the first time.
- - A 39-year-old male presented classic symptoms of ACD and was found to have trypomastigote forms of the parasite, indicating cardiac involvement, which was confirmed through a thick blood drop test.
- - The case highlighted the risks associated with deforestation and colonization, showing that these factors enhance vector transmission of CD, as the patient’s environment contained evidence of the parasite and treatment resulted in successful clearance of the infection.
Introduction: Cancer care providers have faced many challenges in delivering safe care for patients during the COVID-19 pandemic. This cross-sectional survey-based study investigated the impact of the pandemic on clinical practices of Portuguese medical oncologists caring for patients with breast cancer.
Methods: An anonymous online survey comprising 42 questions gathered information regarding COVID-19 testing, treatment in (neo)adjuvant and metastatic settings, and other aspects of breast cancer management.
Article Synopsis
- Breast cancer is the most common cancer in women and its connection to gut microbiota has been studied, revealing that microbiota imbalances can influence its development and treatment.
- In postmenopausal breast cancer patients, differences in gut bacteria compared to healthy individuals have been noted, particularly with bacteria affecting hormone levels that could increase cancer risk.
- The review explores how both gut and breast microbiota may contribute to cancer progression, along with the potential for using microbiome analysis to tailor more personalized treatment strategies for breast cancer.
Article Synopsis
- The paper explores the use of reactive MgO as a sustainable alternative to cement in mortar production, testing six different MgOs from Australia, Canada, and Spain as partial cement substitutes in varying percentages (5% to 25%).
- The study analyzes mechanical properties through various tests, revealing that a 25% reactive MgO substitution can significantly reduce compressive strength by 28% to 49%, while having a lesser impact on other strength properties.
- Additionally, it examines the durability of MgO mortars, finding that some formulations can reduce shrinkage by over 50%, and evaluates water absorption to further assess performance.
Ethical issues that arise during the care of a pregnant woman with cancer are challenging to physicians, policymakers, lawyers, and the bioethics community. The main purpose of this scoping review is to summarize existing literature regarding the bioethical dilemmas when a conflict arises in the maternal-fetus dyad, like the one related to cancer and pregnancy outcomes. Moreover, we illustrate the decision-making process of real-life case reports.
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- This paper reviews the characteristics of MgO (magnesium oxide) and its role in cement-based materials, discussing production processes, reactivity, and key physical properties.
- The impact of MgO on the mechanical strength and durability of cement pastes, mortars, and concrete is examined, focusing on various performance metrics like compressive strength and water absorption.
- It concludes that while MgO can reduce mechanical strength and shrinkage, it often increases porosity and carbonation, highlighting the importance of specific MgO properties, such as calcination temperature and reactivity.
The aim of this prospective registry is to evaluate a new algorithm designed to reduce the percentage of unnecessary ventricular pacing (%VP) in patients implanted with a dual-chamber pacemaker, through a dedicated pacing mode (called AAISafeR2) operating in AAI mode with back-up ventricular pacing in DDD mode, and to describe the incidence and distribution of atrioventricular (AV) block in this population. Investigators were free to assign patients to AAISafeR2 mode or to standard DDD (if AAISafeR was contraindicated, mainly due to permanent high-degree AV block). Patients underwent routine follow-up visits at 3, 6, 12, 18 and 24 months after implantation.
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