Publications by authors named "Jose Nevado"
Article Synopsis
- - Type 2 diabetes mellitus (T2DM) significantly impacts the quality of life for many Filipinos, with genetic factors contributing to 30-70% of the disease risk.
- - This study examined the genetic variants linked to T2DM among Filipinos by comparing 66 individuals with diabetes to 121 without, identifying nine significant genetic variants tied to glucose and energy metabolism.
- - Key variants, particularly CDKAL1 (rs7766070), show the highest risk levels, suggesting their potential use as markers for early detection and prevention of T2DM in the Filipino population.
Background: Coronary artery disease (CAD) is a common complication of Type 2 diabetes mellitus (T2DM). Understanding the pathogenesis of this complication is essential in both diagnosis and management. Thus, this study aimed to characterize the presence of CAD in T2DM using molecular markers and pathway analyses.
View Article and Find Full Text PDFBackground: Infection can be severely complicated by a dysregulated, whole-body inflammatory response known as sepsis. While previous research showed that genetic predisposition is linked to outcome differences, current patient characterization fails to determine which septic patients have greater tendencies to develop into severe sepsis or go into septic shock. As such, the identification of prognostic biomarkers may assist in identifying these high-risk patients and help improve the clinical management of the disease.
View Article and Find Full Text PDFArticle Synopsis
- Sulfonylureas (SUs), like gliclazide and glimepiride, are commonly used medications for managing type 2 diabetes in the Philippines, and the study aimed to explore the genetic factors affecting their effectiveness.
- The research involved 252 participants across two studies, where genetic testing was conducted to identify associations between genetic variants and the individual responses to these medications.
- Results showed that certain genetic variants were significantly linked to poor responses to gliclazide and glimepiride, suggesting that understanding these genetic factors could improve treatment strategies for diabetes in the Filipino population.
Nutritional and genetic determinants of essential hypertension among adult respondents of the 2013 national nutrition survey, Philippines: a preliminary observational study.
J Nutr Biochem
December 2022
Preventive strategies for hypertension and its sequelae require an understanding of their predisposing conditions and recognition of at-risk individuals. Several factors, both genetic and nongenetic, are influential, and likely vary in their effects across ethnicities. This study aimed to identify dietary, lifestyle-related differences and genetic variants associated with hypertension in Filipinos.
View Article and Find Full Text PDFPurpose: A study among Filipinos revealed that only 15% of patients with diabetes achieved glycemic control, and poor response to metformin could be one of the possible reasons. Recent studies demonstrate how genetic variations influence response to metformin. Hence, the present study aimed to determine genetic variants associated with poor response to metformin.
View Article and Find Full Text PDFGenetic variation is known to affect response to calcium channel blockers (CCBs) among different populations. This study aimed to determine the genetic variations associated with poor response to this class of antihypertensive drugs among Filipinos.One hundred eighty one hypertensive participants on CCBs therapy were included in an unmatched case-control study.
View Article and Find Full Text PDFPrevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm).
Hum Genome Var
February 2021
Article Synopsis
- Pharmacogenomics can improve drug treatment outcomes by using genetic testing to enhance drug effectiveness and reduce severe side effects.
- Next-generation sequencing (NGS) allows for simultaneous genotyping of multiple pharmacogenomic loci, leading to greater data availability.
- A study resequenced 100 pharmacogenes in Southeast Asian populations, revealing significant genetic variations that could explain differences in drug responses among populations.
Hypoxia leading to stabilization of hypoxia-inducible factor 1α (HIF-1α) serves as an early upstream initiator for adipose tissue (AT) dysfunction. Monocyte-derived macrophage infiltration in AT contributes to inflammation, fibrosis and obesity-related metabolic dysfunction. It was previously reported that myeloid cell-specific deletion of protected against high-fat diet (HFD)-induced AT dysfunction.
View Article and Find Full Text PDFA common drug used for hypertension among Filipinos is beta-blockers. Variable responses to beta-blockers are observed, and genetic predisposition is suggested. This study investigated the association of genetic variants with poor response to beta-blockers among Filipinos.
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- Veins grafted into arteries undergo complex changes, which can lead to blockages in the grafts.
- Understanding this process is crucial for improving surgery outcomes in patients with heart and artery diseases.
- Research shows that a type of cell transition, called endothelial-to-mesenchymal transition (EndMT), contributes to these changes, and targeting the TGF-β signaling pathway may help reduce complications like stenosis in vein grafts.
Folic acid-based intervention in non-ST elevation acute coronary syndromes.
Asian Cardiovasc Thorac Ann
January 2009
Homocysteinemia is a risk factor for cardiovascular diseases. Folic acid combined with vitamins B(6) and B(12) is effective in lowering homocysteine levels. This randomized placebo-controlled study was designed to determine the effect of a folic acid-based supplement on secondary prevention of clinical events in non-ST-segment elevation acute coronary syndromes.
View Article and Find Full Text PDFBackground: Unstable angina and non-ST elevation myocardial infarction (NSTEMI) are common acute coronary events. Homocysteine is a novel risk factor for coronary heart diseases. Together with the conventional risk factors, they may affect the outcome of non-ST coronary events.
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