The overturn of Roe v. Wade beyond abortion: a snapshot of methotrexate accessibility for people with rheumatic and musculoskeletal diseases-a mixed methods study using Twitter data.

In June 2022, the Supreme Court of the United States (US) overturned the right established in Roe v. Wade to terminate a pregnancy. Subsequently, some states passed abortion ban laws prohibiting the use of abortive methods, including methotrexate (MTX), which has been a cornerstone drug in rheumatology.

Patient perspectives on long-term outcomes in rheumatoid arthritis. A qualitative study from the OMERACT patient outcomes in longitudinal studies working group.

Objectives: To identify patient-centered domains with long-term relevance to people with rheumatoid arthritis (RA).

Methods: We conducted semi-structured individual cognitive interviews of patients with RA with at least five years of disease duration, sampled from five different countries (United States, Italy, Spain, Mexico, and Argentina). Participants were encouraged to discuss their long-term concerns regarding RA.

Development of a patient-centered core domain set for prospective observational longitudinal outcome studies in rheumatoid arthritis: an OMERACT initiative.

Objectives: To identify patient-centered core domains for prospective longitudinal observational studies (LOS) in rheumatoid arthritis.

Methods: Our working group held a virtual meeting in November 2020 to review data from a literature review and patient qualitative interviews, and to discuss strategies to move forward on domain identification and selection using the OMERACT 2.1 domain selection process.

Prevention, screening, assessing and managing of non-adherent behaviour in people with rheumatic and musculoskeletal diseases: systematic reviews informing the 2020 EULAR points to consider.

Objective: To analyse how non-adherence to prescribed treatments might be prevented, screened, assessed and managed in people with rheumatic and musculoskeletal diseases (RMDs).

Methods: An overview of systematic reviews (SR) was performed in four bibliographic databases. Research questions focused on: (1) effective interventions or strategies, (2) associated factors, (3) impact of shared decision making and effective communication, (4) practical things to prevent non-adherence, (5) effect of non-adherence on outcome, (6) screening and assessment tools and (7) responsible healthcare providers.

Within-Stand Distribution of Tree Mortality Caused by Mountain Pine Beetle, Hopkins.

The mountain pine beetle (MPB) () is a bark beetle that attacks and kills ponderosa pine (), among other pine species throughout the western conifer forests of the United States and Canada, particularly in dense stands comprising large trees. There is information on the stand conditions that the insect prefers. However, there is a paucity of information on how small-scale variation in stand conditions influences the distribution of tree mortality within a stand.

The Clinical Genome and Ancestry Report: An interactive web application for prioritizing clinically implicated variants from genome sequencing data with ancestry composition.

Genome sequencing is positioned as a routine clinical work-up for diverse clinical conditions. A commonly used approach to highlight candidate variants with potential clinical implication is to search over locus- and gene-centric knowledge databases. Most web-based applications allow a federated query across diverse databases for a single variant; however, sifting through a large number of genomic variants with combination of filtering criteria is a substantial challenge.

Cryptic Species Discrimination in Western Pine Beetle, LeConte (Curculionidae: Scolytinae), Based on Morphological Characters and Geometric Morphometrics.

The western pine beetle (WPB), LeConte, is a major mortality agent of pines in North America. A total of 706 adults of WPB from 81 geographical sites were analyzed with traditional and geometric morphometric methods to evaluate the variation of discrete and quantitative morphological characters with particular attention to the antenna, spermatheca, and seminal rod. Principal coordinates and canonical variate analyses supported three geographical groups in WPB: (1) West, from British Columbia to southern California along the Pacific coast, Idaho, and Montana; (2) East-SMOC, including Nevada, Utah, Colorado, Arizona, New Mexico, Texas, Chihuahua, and Durango; and (3) SMOR, including Coahuila, Nuevo Leon, and Tamaulipas.

"There is something you must see": breaking down the remission concept in rheumatoid arthritis from a rheumatologist's perspective.

Objectives: To explore the remission concept in rheumatoid arthritis (RA) and the implications of the existing definitions when applied to clinical practice among rheumatologists with different profiles.

Methods: A qualitative study through focus groups was conducted. Three focus groups were organised from February to March 2016.

Comparative analysis of whole-genome sequencing pipelines to minimize false negative findings.

Comprehensive and accurate detection of variants from whole-genome sequencing (WGS) is a strong prerequisite for translational genomic medicine; however, low concordance between analytic pipelines is an outstanding challenge. We processed a European and an African WGS samples with 70 analytic pipelines comprising the combination of 7 short-read aligners and 10 variant calling algorithms (VCAs), and observed remarkable differences in the number of variants called by different pipelines (max/min ratio: 1.3~3.

Core Outcome Sets Specifically for Longterm Observational Studies: OMERACT Special Interest Group Update in Rheumatoid Arthritis.

Objective: This is an update from the Outcome Measures in Rheumatology (OMERACT) Core Outcomes in Longterm Observational Studies Special Interest Group with a focus on rheumatoid arthritis.

Methods: Preliminary data and proposed next steps were outlined and discussed by participants.

Results: Domains identified after initial steps (systematic review and qualitative research) were pain, physical functioning, participation (i.

#EULAR2018: The Annual European Congress of Rheumatology-a Twitter hashtag analysis.

The objective of this study was to explore the hashtag #EULAR2018 on Twitter during the period of the European League Against Rheumatism (EULAR) Annual European Congress to better comprehend the implications and patterns of social media (SM) data and their possible impact on users interested in rheumatic and musculoskeletal diseases. A mixed methods study combining SM performance data with qualitative content analysis of tweets was conducted. All the tweets publicly posted with #EULAR2018 were tracked using Symplur™ and Keyhole.

HoTResDB: host transcriptional response database for viral hemorrhagic fevers.

Summary: High-throughput screening of the host transcriptional response to various viral infections provides a wealth of data, but utilization of microarray and next generation sequencing (NGS) data for analysis can be difficult. The Host Transcriptional Response DataBase (HoTResDB), allows visitors to access already processed microarray and NGS data from non-human primate models of viral hemorrhagic fever to better understand the host transcriptional response.

Availability: HoTResDB is freely available at http://hotresdb.

The Current Status of the Distribution Range of the Western Pine Beetle, Dendroctonus brevicomis (Curculionidae: Solytinae) in Northern Mexico.

The distribution range of the western pine beetle Dendroctonus brevicomis LeConte (Coleoptera: Curculionidae) is supported only by scattered records in the northern parts of Mexico, suggesting that its populations may be marginal and rare in this region. In this study, we review the geographical distribution of D. brevicomis in northern Mexico and perform a geometric morphometric analysis of seminal rod shape to evaluate its reliability for identifying this species with respect to other members of the Dendroctonus frontalis Zimmermann (Coleoptera: Curculionidae) complex.

Evidence of compounded disturbance effects on vegetation recovery following high-severity wildfire and spruce beetle outbreak.

Spruce beetle (Dendroctonus rufipennis) outbreaks are rapidly spreading throughout subalpine forests of the Rocky Mountains, raising concerns that altered fuel structures may increase the ecological severity of wildfires. Although many recent studies have found no conclusive link between beetle outbreaks and increased fire size or canopy mortality, few studies have addressed whether these combined disturbances produce compounded effects on short-term vegetation recovery. We tested for an effect of spruce beetle outbreak severity on vegetation recovery in the West Fork Complex fire in southwestern Colorado, USA, where much of the burn area had been affected by severe spruce beetle outbreaks in the decade prior to the fire.

Exploring the remission concept in rheumatoid arthritis with patients and rheumatologists: time for a new approach?

Objectives: To explore the remission concept in rheumatoid arthritis (RA) and to compare remission definitions and related concepts between rheumatologists and patients with the purpose of identifying similarities and disparities to comprehend the different perspectives of the disease.

Methods: This was a qualitative study of discourse and content analysis through focus groups, conducted from February to March 2016. Four focus groups were set up, each one with different interests: rheumatologists involved in basic research (BR), rheumatologists with high specialisation in imaging techniques (IR), clinical rheumatologists (CR), and patients (PA).

Mountain Pine Beetle Host Selection Between Lodgepole and Ponderosa Pines in the Southern Rocky Mountains.

Recent evidence of range expansion and host transition by mountain pine beetle (Dendroctonus ponderosae Hopkins; MPB) has suggested that MPB may not primarily breed in their natal host, but will switch hosts to an alternate tree species. As MPB populations expanded in lodgepole pine forests in the southern Rocky Mountains, we investigated the potential for movement into adjacent ponderosa pine forests. We conducted field and laboratory experiments to evaluate four aspects of MPB population dynamics and host selection behavior in the two hosts: emergence timing, sex ratios, host choice, and reproductive success.

Notes from the field: elemental mercury spill in school bus and residence - North Carolina, 2013.

On September 16, 2013, the North Carolina Division of Public Health was notified of an elemental (metallic and liquid) mercury spill on a school bus. An elementary student boarded the bus with approximately 1 pound (454 g) of elemental mercury contained in a film canister, which the student had taken from an adult relative who had found it in a neighbor's shed. The canister was handled by several students before the contents spilled on the bus floor.

Persistent reduced ecosystem respiration after insect disturbance in high elevation forests.

Amid a worldwide increase in tree mortality, mountain pine beetles (Dendroctonus ponderosae Hopkins) have led to the death of billions of trees from Mexico to Alaska since 2000. This is predicted to have important carbon, water and energy balance feedbacks on the Earth system. Counter to current projections, we show that on a decadal scale, tree mortality causes no increase in ecosystem respiration from scales of several square metres up to an 84 km(2) valley.

Effects of mountain pine beetle on fuels and expected fire behavior in lodgepole pine forests, Colorado, USA.

In Colorado and southern Wyoming, mountain pine beetle (MPB) has affected over 1.6 million ha of predominantly lodgepole pine forests, raising concerns about effects of MPB-caused mortality on subsequent wildfire risk and behavior. Using empirical data we modeled potential fire behavior across a gradient of wind speeds and moisture scenarios in Green stands compared three stages since MPB attack (Red [1-3 yrs], Grey [4-10 yrs], and Old-MPB [∼30 yrs]).

Semiochemical-mediated flight strategies of two invasive elm bark beetles: a potential factor in competitive displacement.

A seven-state survey showed that the recently detected invasive Asian banded elm bark beetle, Scolytus schevyrewi Semenov, was abundant in areas of Colorado and Wyoming, whereas the long-established European elm bark beetle, S. multistriatus (Marsham), was not as abundant. In one of a series of studies to evaluate whether S.

Traps and attractants for wood-boring insects in ponderosa pine stands in the Black Hills, South Dakota.

Recent large-scale wildfires have increased populations of wood-boring insects in the Black Hills of South Dakota. Because little is known about possible impacts of wood-boring insects in the Black Hills, land managers are interested in developing monitoring techniques such as flight trapping with semiochemical baits. Two trap designs and four semiochemical attractants were tested in a recently burned ponderosa pine, Pinus ponderosa Dougl.