Publications by authors named "Jose N Alcala-Pedrajas"
Article Synopsis
- - The study investigates the relationship between COVID-19 and heart failure (HF), focusing on identifying risk factors for HF among hospitalized COVID-19 patients in Spain.
- - A total of 16,474 patients were analyzed, with 5.8% developing HF; significant risk factors included older age, atrial fibrillation, obesity, and peripheral vascular disease.
- - Patients who developed HF had notably higher mortality rates, increased need for intubation, and higher ICU admission rates compared to those who did not develop HF.
Background: The WHO ordinal severity scale has been used to predict mortality and guide trials in COVID-19. However, it has its limitations.
Objective: The present study aims to compare three classificatory and predictive models: the WHO ordinal severity scale, the model based on inflammation grades, and the hybrid model.
Objective: To compare coronavirus disease 2019 (COVID-19) hospitalization outcomes between persons with and without HIV.
Design: Retrospective observational cohort study in 150 hospitals in Spain.
Methods: Patients admitted from 1 March to 8 October 2020 with COVID-19 diagnosis confirmed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 positive) PCR test in respiratory tract samples.
Uncontrolled inflammation following COVID-19 infection is an important characteristic of the most seriously ill patients. The present study aims to describe the clusters of inflammation in COVID-19 and to analyze their prognostic role. This is a retrospective observational study including 15,691 patients with a high degree of inflammation.
View Article and Find Full Text PDFAcetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in hospitalized COVID-19 patients. We realized an observational retrospective cohort study of 20,641 patients with COVID-19 pneumonia collected and followed-up from Mar 1st, 2020 to May 1st, 2021, from the nationwide Spanish SEMI-COVID-19 Registry.
View Article and Find Full Text PDFWe aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.
View Article and Find Full Text PDFSystolic Blood Pressure and Outcomes in Stable Outpatients with Recent Symptomatic Artery Disease: A Population-Based Longitudinal Study.
Int J Environ Res Public Health
September 2021
Objectives: The most appropriate targets for systolic blood pressure (SBP) levels to reduce cardiovascular morbidity and mortality in patients with symptomatic artery disease remain controversial. We compared the rate of subsequent ischemic events or death according to mean SBP levels during follow-up.
Design: Prospective cohort study.
Background: The effects of cardiometabolic drugs on the prognosis of diabetic patients with COVID-19, especially very old patients, are not well known. This work was aimed to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ≥80 years with type 2 diabetes mellitus (T2DM) hospitalized for COVID-19.
Method: We conducted a nationwide, multicenter, observational study in patients ≥80 years with T2DM hospitalized for COVID-19 between March 1 and May 29, 2020.
Article Synopsis
- The study investigates different clinical presentations of COVID-19 pneumonia by analyzing 12,066 patients to identify distinct phenotypes and their prognostic significance.
- The cluster analysis revealed four clinical phenotypes, with the majority exhibiting a triad of fever, cough, and dyspnea, while specific additional symptoms varied among the clusters.
- Cluster C1, which represents the largest group, showed the highest in-hospital mortality rate (24.1%) compared to the other clusters, highlighting the importance of specific clinical features in predicting outcomes.
Objective: To compare the mortality rate and the rate of subsequent ischemic events (myocardial infarction [MI], ischemic stroke, or limb amputation) in patients with recent MI according to the use of cardiac rehabilitation or no rehabilitation.
Design: Longitudinal observational study.
Setting: Ongoing registry of outpatients.