Publications by authors named "Jose Monteiro Sad Pereira"
Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats.
José Monteiro Sad Pereira André Luis Barreira Conrado Rodrigues Gomes Felipe Mateus Ornellas Débora Santos Ornellas
BMC Nephrol
May 2020
Article Synopsis
- The study explores the role of purinergic P2X7 receptors (P2X7R) in kidney inflammation, apoptosis, and fibrosis following unilateral ureteral obstruction (UUO) in rats, specifically focusing on the effects at the three-day mark after UUO.
- Researchers administered a selective P2X7R inhibitor, brilliant blue G (BBG), to different groups of rats (UUO-BBG and UUO-V), analyzing kidney samples for various markers of inflammation and damage.
- Results indicated that BBG reduced the expression of inflammatory markers and renal cell apoptosis while promoting epithelial cell proliferation compared to the control group, suggesting its potential therapeutic role in managing kidney damage due to UUO.