Publications by authors named "Jose Milton de Castro Lima"
Effectiveness and Safety of Direct-Acting Antivirals in the Treatment of Chronic Hepatitis C: A Real-life Study in Northeastern Brazil.
Rev Soc Bras Med Trop
November 2024
Article Synopsis
- The study evaluated the effectiveness and safety of direct-acting antivirals (DAAs) for hepatitis C, focusing on sustained virologic response (SVR) and serious adverse events among patients in Ceará, Brazil.
- A total of 1075 patients were analyzed, with a high overall SVR rate of 96.4%; however, those with cirrhosis showed slightly lower SVR rates compared to patients with less severe fibrosis.
- While DAAs were generally safe, a small percentage (3.5%) of patients experienced serious adverse events, and some decompensated cirrhosis patients faced mortality during treatment.
Introduction: Hepatitis B virus (HBV) infection is a public health problem; therefore, we aimed to report HBV genotypes in Ceará, Brazil.
Methods: A total of 103 HBsAg-positive samples were subjected to HBV genotyping and subgenotyping.
Results: The following genetic compositions of samples were found: F-54% (F2-83.
Effectiveness of first-wave protease inhibitors in hepatitis C virus genotype 1 infection: a multicenter study in Brazil.
Rev Soc Bras Med Trop
April 2018
Introduction: In 2013, combination therapy using peginterferon, ribavirin, and boceprevir or telaprevir was introduced to treat hepatitis C virus genotype 1 infection in Brazil. The effectiveness of this therapy in four Brazilian regions was evaluated.
Methods: Clinical and virological data were obtained from patients of public health institutions in five cities, including sustained virological response (SVR) and side effects.
Hepatocellular adenomas (HCAs) are rare benign monoclonal hepatic tumors that commonly occur in females (3-4 per 100,000 women) due to the use of oral contraceptives, its primary risk factor. Recently, HCAs have been classified into 4 distinct subtypes according to genotypic and phenotypic characteristics and clinical features: inflammatory HCA (40-50%), which are hypervascular with marked peliosis and a tendency to bleed; hepatocyte nuclear factor 1α (HNF1A)-mutated HCA (H-HCA, 30-40%) that are diffusely steatotic and rarely undergo malignant transformation; β-catenin activated HCA (10-15%), which frequently undergo malignant transformation and may seem hepatocellular carcinoma on imaging; and unclassified HCA (10-25%). In this study, we report the case of a 23-year-old female oral contraceptive user with H-HCA.
View Article and Find Full Text PDFThe spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors.
Acta Cir Bras
November 2013
Article Synopsis
- The study aimed to find out how common non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are among morbidly obese patients about to have bariatric surgery and to pinpoint related risk factors.
- A liver biopsy performed on 60 patients revealed that 95% had NAFLD, with 66.7% diagnosed with NASH; only a small number showed severe liver damage (3 patients with fibrosis).
- The findings indicate that NAFLD is prevalent in morbidly obese patients, and the enzyme γGT was identified as a key predictor of the level of fat in their livers.
Objective: The prevalence of hepatitis C virus (HCV) is higher in patients on hemodialysis than in the general population, probably due to greater exposure to risk situations. The purposes of the study were to determine anti-HCV antibodies prevalence among hemodialysis patients and dialysis clinics and patients factors associated with HCV transmission.
Methods: A cross-sectional study was conducted in 752 hemodialysis patients in all 12 dialysis clinics of Fortaleza, Brazil, and were screened using third generation ELISA.