Publications by authors named "Jose Michieli"
Article Synopsis
- Diabetic peripheral neuropathy is a common diabetes complication that leads to serious issues like pain, ulcers, and amputations.
- Researchers induced diabetes in male Wistar rats using streptozotocin (STZ) and examined the impact of BKB1-R on oxidative stress and Na+-K+ ATPase activity in nervous tissues.
- The study found that hyperglycemia caused electrical dysfunction and increased oxidative stress in the sciatic nerve, but treatment with BKB1 antagonist R-954 improved neuronal activity and reduced oxidative stress, indicating potential therapeutic benefits for diabetic neuropathy.
