Inorganic Nanorods Enable the Memorization of Photoinduced Microlens Arrays in Dye-Doped Liquid Crystals.

The photoinduced molecular reorientation of liquid crystals (LCs) caused by their nonlinear optical responses has attracted much attention due to their large refractive index change, leading to promising applications in optical devices. This reorientation is typically induced by light irradiation above a threshold intensity and is temporary, with the initial orientation recovering unless the LCs are polymerized and cross-linked. Our report highlights the memory effect of molecular reorientation in LCs.

Pseudo-Synchronous Colorectal Cancer: A Case Report.

Colorectal cancer is one of the most common malignancies in men and women. Its metastatic pattern is predicted depending on the location, with aggressivity and local spread more common in the mucinous types. The incidence has been higher over the last decade due to increased screening.

The Natural History of Post-Chikungunya Viral Arthritis Disease Activity and T-cell Immunology: A Cohort Study.

Background: Chikungunya virus (CHIKV) is an alphavirus spread by mosquitos that causes arthralgias and arthritis that may last for years. The objective of this study was to describe the arthritis progression and T cell immunology over a two-year period.

Methods: A cohort of 40 cases of serologically confirmed CHIKV from Magdalena and Atlántico, Colombia were followed in 2019 and again in 2021.

Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study.

Objective: To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy.

Methods: Participants with chikungunya arthritis were recruited from Colombia from 2019-2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis.

The Importance of Clinical Reasoning in Pancreatic Insufficiency: A Case Report.

Evidence-based medicine has demonstrated an extensive list of etiologies for exocrine pancreatic insufficiency (EPI). EPI is defined as inadequate pancreatic enzyme efficacy in digestion due to insufficient enzyme production, activation, or early enzyme degradation. Among the etiologies, acute pancreatitis secondary to chronic and excessive consumption of alcohol has been found to be one of the most common causes.

Adaptive filter with Riemannian manifold constraint.

The adaptive filtering theory has been extensively developed, and most of the proposed algorithms work under the assumption of Euclidean space. However, in many applications, the data to be processed comes from a non-linear manifold. In this article, we propose an alternative adaptive filter that works on a manifold, thus generalizing the filtering task to non-Euclidean spaces.

COVID-19 Exposure Unmasking Systemic Amyloidosis With Hepatic Predominance.

Amyloidosis is characterized by depositing insoluble fibrillar proteins that misfold into beta-pleated sheets. This phenomenon occurs on a systemic or local level and may interfere with the function of various organs, including the heart, kidneys, and liver. Among those presenting with amyloidosis, hepatic, gastrointestinal, renal, cardiac, vitreous, and immunological involvement may occur.

Estimation of systolic blood pressure by Random Forest using heart sounds and a ballistocardiogram.

Cuffless blood pressure measurement enables unobtrusive and continuous monitoring that can be integrated with wearable devices to extend healthcare to non-hospital settings. Most of the current research has focused on the estimation of blood pressure based on pulse transit time or pulse arrival time using ECG or peripheral cardiac pulse signals as proximal time references. This study proposed the use of a phonocardiogram (PCG) and ballistocardiogram (BCG), two signals detected noninvasively, to estimate systolic blood pressure (SBP).

Chronic urticaria associated with lung adenocarcinoma - a paraneoplastic manifestation: A case report and literature review.

Background: Urticaria is one of the most common causes of emergency room visits. It is defined as an acute inflammatory dermatosis, characterized by localized degranulation of mast cells, with consequent dermal microvascular and formation of edematous and pruritic plaques called hives. Urticaria affects the skin and tissues of the superficial mucosa.

Separation of the Ca 1.2-Ca 1.3 calcium channel duo prevents type 2 allergic airway inflammation.

Background: Voltage-gated calcium (Ca 1) channels contribute to T-lymphocyte activation. Ca 1.2 and Ca 1.

Ageing of T-dependent B cell responses.

The human immune system is in continuous interaction with environmental factors (pathogens, exercise, stress, pollutants, diet, vaccines, and therapeutics) that condition its efficiency by promoting or moderating multiple immune mechanisms. While the deleterious impact of external factors can be avoided or limited, the immune system itself grows weaker with age. Immune cells persist in the elderly, and the observed decline of cellular immunity is related to cellular senescence.

Survey data on the impact of COVID-19 on parental engagement across 23 countries.

This data article describes the dataset of the International COVID-19 Impact on Parental Engagement Study (ICIPES). ICIPES is a collaborative effort of more than 20 institutions to investigate the ways in which, parents and caregivers built capacity engaged with children's learning during the period of social distancing arising from global COVID-19 pandemic. A series of data were collected using an online survey conducted in 23 countries and had a total sample of 4,658 parents/caregivers.

TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women.

Type I IFN (IFN-I) production by plasmacytoid DCs (pDCs) occurs during acute HIV-1 infection in response to TLR7 stimulation, but the role of pDC-derived IFN-I in controlling or promoting HIV-1 infection is ambiguous. We report here a sex-biased interferogenic phenotype for a frequent single-nucleotide polymorphism of human TLR7, rs179008, displaying an impact on key parameters of acute HIV-1 infection. We show allele rs179008 T to determine lower TLR7 protein abundance in cells from women, specifically - likely by diminishing TLR7 mRNA translation efficiency through codon usage.

Gait Biomarkers Classification by Combining Assembled Algorithms and Deep Learning: Results of a Local Study.

Machine learning, one of the core disciplines of artificial intelligence, is an approach whose main emphasis is analytical model building. In other words, machine learning enables an automaton to make its own decisions based on a previous training process. Machine learning has revolutionized every research sector, including health care, by providing precise and accurate decisions involving minimal human interventions through pattern recognition.

Long-term immunity against yellow fever in children vaccinated during infancy: a longitudinal cohort study.

Background: A single dose of vaccine against yellow fever is routinely administered to infants aged 9-12 months under the Expanded Programme on Immunization, but the long-term outcome of vaccination in this age group is unknown. We aimed to evaluate the long-term persistence of neutralising antibodies to yellow fever virus following routine vaccination in infancy.

Methods: We did a longitudinal cohort study, using a microneutralisation assay to measure protective antibodies against yellow fever in Malian and Ghanaian children vaccinated around age 9 months and followed up for 4·5 years (Mali), or 2·3 and 6·0 years (Ghana).

[Analgesic effect, phytochemical characterization and toxicological analysis of ethanolic extract of pereskia lychnidiflora leaves].

Objective: To evaluate the analgesic effect of the ethanolic extract of the leaves of Pereskia lychnidiflora, the prospection of secondary metabolites and the toxicologic analysis.

Materials And Methods: Analgesic activity was evaluated by testing acetic acid and formalin in NIH mice at a concentration of 30, 50 and 100 mg/kg body weight, using Ibuprofen control at 200 mg/kg and distilled water as the target. Secondary metabolites were prospected using the thin layer chromatography method and the toxicity of the extract was evaluated in vivo according to the maximum dose of 2,000 mg/kg body weight.

Reconstruction of PET Images Using Cross-Entropy and Field of Experts.

The reconstruction of positron emission tomography data is a difficult task, particularly at low count rates because Poisson noise has a significant influence on the statistical uncertainty of positron emission tomography (PET) measurements. Prior information is frequently used to improve image quality. In this paper, we propose the use of a field of experts to model a priori structure and capture anatomical spatial dependencies of the PET images to address the problems of noise and low count data, which make the reconstruction of the image difficult.

Reconstruction of Positron Emission Tomography Images Using Gaussian Curvature.

Positron emission tomography (PET) provides images of metabolic activity in the body, and it is used in the research, monitoring, and diagnosis of several diseases. However, the raw data produced by the scanner are severely corrupted by noise, causing a degraded quality in the reconstructed images. In this paper, we proposed a reconstruction algorithm to improve the image reconstruction process, addressing the problem from a variational geometric perspective.

Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation.

Women develop stronger immune responses than men, with positive effects on the resistance to viral or bacterial infections but magnifying also the susceptibility to autoimmune diseases like systemic lupus erythematosus (SLE). In SLE, the dosage of the endosomal Toll-like receptor 7 (TLR7) is crucial. Murine models have shown that TLR7 overexpression suffices to induce spontaneous lupus-like disease.

Perinatal MAO Inhibition Produces Long-Lasting Impairment of Serotonin Function in Offspring.

In addition to transmitter functions, many neuroamines have trophic or ontogenetic regulatory effects important to both normal and disordered brain development. In previous work (Mejia et al., 2002), we showed that pharmacologically inhibiting monoamine oxidase (MAO) activity during murine gestation increases the prevalence of behaviors thought to reflect impulsivity and aggression.

escapes X chromosome inactivation in immune cells.

Toll-like receptor 7 (TLR7) is critical to the induction of antiviral immunity, but TLR7 dosage is also a key pathogenic factor in systemic lupus erythematosus (SLE), an autoimmune disease with strong female bias. SLE prevalence is also elevated in individuals with Klinefelter syndrome, who carry one or more supernumerary X chromosomes, suggesting that the X chromosome complement contributes to SLE susceptibility. TLR7 is encoded by an X chromosome locus, and we examined here whether the gene evades silencing by X chromosome inactivation in immune cells from women and Klinefelter syndrome males.