Publications by authors named "Jose Martinez Sande"
Article Synopsis
- Cardioneuroablation (CNA) is a therapy for conditions like vasovagal syncope, atrioventricular block, and sinus node dysfunction, but its effectiveness for patients over 50 is unclear.
- In a study with 50 patients divided into two age groups (under 50 vs. 50 and above), there was no significant difference in survival rates without syncope or the need for pacemakers between the groups after a median follow-up of 17 months.
- Older patients had lower heart rate post-procedure compared to younger patients, but both age groups showed similar improvements in quality of life and a decrease in heart rate variability.
Article Synopsis
- Carotid sinus syndrome (CSS) leads to severe vagal responses and often requires pacemaker implantation, but this study explores cardioneuroablation (CNA) as a potential alternative treatment.
- The study included 13 patients who underwent various tests before and after the CNA procedure, aiming for no cardioinhibitory response post-treatment and analyzing quality of life improvements.
- Results showed that, after CNA, all but one patient had a negative response to carotid sinus massage, with 84.6% remaining free from syncope and no one needing a pacemaker, indicating CNA may effectively reduce syncopal episodes in CSS patients.
Introduction And Objectives: We report the results of the 2023 Spanish catheter ablation registry.
Methods: Procedural data were collected and incorporated into the REDCap platform by all participating centers through a specific form.
Results: There were 104 participating centers in 2023 compared with 103 in 2022.
Article Synopsis
- Atrial fibrosis impacts the success of ablation procedures, with extensive fibrosis potentially reducing atrial excitability.
- The study aimed to determine clinical factors linked to extensive left atrial myopathy (ELAM) and evaluate the effectiveness of existing prediction scores for assessing outcomes related to atrial fibrillation (AF) recurrence.
- Results showed that 8.4% of patients had ELAM, with predictors being age, female sex, persistent AF, and first-degree AV block, leading to higher rates of AF recurrence and heart failure admissions compared to non-ELAM patients.
Background And Aims: Prior reports have demonstrated a favourable safety and efficacy profile of the Micra leadless pacemaker over mid-term follow-up; however, long-term outcomes in real-world clinical practice remain unknown. Updated performance of the Micra VR leadless pacemaker through five years from the worldwide post-approval registry (PAR) was assessed.
Methods: All Micra PAR patients undergoing implant attempts were included.
Introduction And Objectives: Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) have been associated with improved prognosis in patients with heart failure, but their impact on atrial arrhythmic (AA) and ventricular arrhythmic (VA) events is not fully understood.
Methods: This multicenter retrospective study included patients with implantable cardioverter-defibrillators who initiated treatment with SGLT2i. AA and VA events were compared in 2 time periods for each patient: 1 year before and 1 year after starting SGLT2i.
Atrial fibrillation (AF) is the most common arrhythmia worldwide, affecting 1% of the population over 60 years old. The incidence and prevalence of AF are increasing globally, representing a relevant health problem, suggesting that more advanced strategies for predicting risk stage are highly needed. miRNAs mediate several processes involved in AF.
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- This study investigates the effectiveness of the sST2 biomarker in predicting the recurrence of atrial fibrillation (AF) in patients undergoing electrical cardioversion (ECV) and pulmonary vein isolation (PVI) procedures.
- The research found that in patients who underwent ECV, sST2 levels at 3 months post-procedure could help predict AF recurrence at 6 months, with moderate accuracy.
- Conversely, in the PVI group, sST2 was not a useful predictor of AF recurrence, indicating its predictive value may vary based on the type of procedure.
Aims: This study aims to investigate the clinical and biochemical characteristics of patients with atrial fibrillation (AF) referred for ablation who develop arrhythmia-induced cardiomyopathy (AiCM) as well as their long-term outcomes after catheter ablation (CA).
Methods And Results: A prospective multicentre study was conducted on consecutive AF patients who underwent CA. AiCM was defined as the development of heart failure in the presence of AF and an improvement of left ventricular fraction by at least 10% at 6 months after ablation.
Gender-related differences have been reported in patients who underwent pulmonary vein isolation (PVI). Atrial substrate plays a role in the outcomes after ablation but gender-related differences in atrial substrate have never been described in detail. We sought to analyze gender-related differences in atrial remodeling (spontaneous low-voltage zones [LVZs]) and their clinical relevance after PVI.
View Article and Find Full Text PDFAtrial fibrillation is the most prevalent tachyarrhythmia in clinical practice, with very high cardiovascular morbidity and mortality with a high-cost impact in health systems. Currently, it is one of the main causes of stroke and subsequent heart failure and sudden death. miRNAs mediate in several processes involved in cardiovascular disease, including fibrosis and electrical and structural remodeling.
View Article and Find Full Text PDFRelaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal processes in the pathogenesis of AF, our aim was to study the relationship between relaxin-2 plasma levels in left atrium (LA) and peripheral vein with molecules implicated in fibrosis, inflammation and oxidative stress in AF patients, and to evaluate the anti-fibrotic ability of relaxin-2 in normal human atrial cardiac fibroblasts (NHCF-A). Peripheral vein relaxin-2 plasma levels were higher than LA relaxin-2 plasma levels in men while, in women, peripheral vein relaxin-2 levels were increased compared to men.
View Article and Find Full Text PDFCharacterization of Atrial Substrate to Predict the Success of Pulmonary Vein Isolation: The Prospective, Multicenter MASH-AF II (Multipolar Atrial Substrate High Density Mapping in Atrial Fibrillation) Study.
J Am Heart Assoc
January 2023
Article Synopsis
- A study analyzed the relationship between low-voltage zones (LVZs) in the left atrium and the recurrence of atrial fibrillation (AF) in patients who underwent pulmonary vein isolation, finding that a higher percentage of LVZs correlated with increased recurrence rates.
- The research involved 262 patients, showing that more than 5% LVZ in paroxysmal AF and over 15% in persistent AF significantly raised the risk of AF recurrence within 28 months.
- The findings suggest that not all LVZs are equally significant in predicting outcomes; some patients may experience AF recurrence without the expected volume of LVZs, indicating complex underlying heart tissue changes.
The Role of Fatty Acid-Binding Protein 4 in the Characterization of Atrial Fibrillation and the Prediction of Outcomes after Catheter Ablation.
Int J Mol Sci
September 2022
Article Synopsis
- The study investigates whether biomarkers associated with fibrosis and adiposity can effectively predict low-voltage areas (LVA) in the heart and the likelihood of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI).
- A total of 299 patients were analyzed, revealing that age, left atrium size, and a new combined score based on AF type and FABP4 levels are significant predictors for both LVA and AF recurrence.
- The findings suggest that incorporating adiposity markers like FABP4 into traditional classifications of atrial cardiomyopathy enhances prediction accuracy for both LVA presence and AF recurrence, while galectin-3 (Gal-3) did not show additional predictive benefits.
Introduction: Device infections constitute a major complication of transvenous pacemakers. Mechanical heart valves (MHV) increase the risk of infective endocarditis (IE) and pacemaker infection, requiring lifelong vitamin K-antagonists (VKA), which may affect patient management. Leadless pacemakers (LP) are associated with low infection rates, posing an attractive option in MHV patients requiring permanent pacing.
View Article and Find Full Text PDFCardiac resynchronization therapy represents a therapeutic option for heart failure drug-refractory patients. However, due to the lack of success in 30% of the cases, there is a demand for an in-depth analysis of individual heterogeneity. In this study, we aimed to evaluate the prognostic value of circulating miRNA differences.
View Article and Find Full Text PDFIn this review, the authors describe evolving alternative strategies for the management of AF, focusing on non-invasive and percutaneous autonomic modulation. This modulation can be achieved - among other approaches - via tragus stimulation, renal denervation, cardiac afferent denervation, alcohol injection in the vein of Marshall, baroreceptor activation therapy and endocardial ganglionated plexi ablation. Although promising, these therapies are currently under investigation but could play a role in the treatment of AF in combination with conventional pulmonary vein isolation in the near future.
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- Early results from Micra trials indicate strong safety and performance, but the impact of anticoagulation status during implant hasn't been thoroughly studied.
- The study aimed to evaluate implant characteristics and complications based on patients' anticoagulation strategies (none, interrupted, or continued) during the Micra device implantation.
- Findings showed that patients without anticoagulation were generally younger and had different medical histories; however, the implant success rate was high across all groups, and complications did not significantly vary with the anticoagulation strategy, implying Micra's safety in all cases.
Article Synopsis
- The study examines the long-term effects of cardiac resynchronization therapy (CRT) on patients with heart failure and reduced left ventricular ejection fraction (LVEF), focusing on changes in LVEF and their impact on mortality.
- It involved 328 heart failure patients over an average follow-up of 4.2 years, observing significant improvements in LVEF and left ventricular end-systolic volume (LVESV) during the first year post-CRT, with some gradual changes continuing over time.
- The findings suggest that ongoing measurements of LVEF after CRT provide better insights into individual mortality risk than a single measurement, highlighting the importance of reverse remodeling, especially in the initial year.