Evaluation of Histidine-Rich Proteins 2 and 3 Gene Deletions in in Endemic Areas of the Brazilian Amazon.

Histidine-rich proteins 2 and 3 gene ( and ) deletions affect the efficacy of rapid diagnostic tests (RDTs) based on the histidine-rich protein 2 (HRP2), compromising the correct identification of the species. Therefore, molecular surveillance is necessary for the investigation of the actual prevalence of this phenomenon and the extent of the disappearance of these genes in these areas and other South American countries, thus guiding national malaria control programs on the appropriate use of RDTs. This study aimed to evaluate the and gene deletion in in endemic areas of the Brazilian Amazon.