Publications by authors named "Jose Maria Reguera"
How can we optimize the diagnostic and therapeutic approach to pneumonia? Expert opinion-based recommendations.
Enferm Infecc Microbiol Clin (Engl Ed)
October 2024
Article Synopsis
- - Pneumonia is a common and serious infectious disease, significantly impacting mortality rates and healthcare resources.
- - The OPENIN Group, comprised of specialists in Infectious Diseases and Microbiology, focuses on improving clinical processes related to pneumonia diagnosis and treatment through a review of existing scientific research.
- - The group's initial meeting in October 2023 addressed optimizing pneumonia diagnosis, possibly reducing antibiotic treatment duration, and exploring the use of immunomodulatory strategies like steroids, leading to expert recommendations based on their findings.
Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA).
Clin Microbiol Infect
February 2024
Objectives: To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and to investigate the effect of clinical management on differences in observed outcomes in a multinational matched cohort study.
Methods: A prospective matched-cohorts study (NCT02709408) was performed in 50 European hospitals from March 2016 to November 2018. The main outcome was 30-day mortality with an active post-discharge follow-up when applied.
Article Synopsis
- - The study aimed to identify risk factors for carbapenem-resistant Enterobacterales (CRE) infections to help improve prevention and trial designs, using a matched case-control method across 50 hospitals from March 2016 to November 2018.
- - It analyzed data from 235 patients with CRE infections (primarily complicated urinary tract infections), 235 with carbapenem-susceptible Enterobacterales (CSE) infections, and 705 non-infected controls, finding key risk factors like previous CRE colonization, urinary catheter use, and exposure to broad-spectrum antibiotics.
- - The findings highlighted that patients with a history of CRE colonization and those who had urinary catheters or received extensive antibiotic treatment were at
Inflammation is a central pathogenic feature of the acute respiratory distress syndrome (ARDS) in COVID-19. Previous pathologies such as diabetes, autoimmune or cardiovascular diseases become risk factors for the severe hyperinflammatory syndrome. A common feature among these risk factors is the subclinical presence of cellular stress, a finding that has gained attention after the discovery that BiP (GRP78), a master regulator of stress, participates in the SARS-CoV-2 recognition.
View Article and Find Full Text PDFObjective: To prove that 7-day courses of antibiotics for bloodstream infections caused by members of the Enterobacterales (eBSIs) allow a reduction in patients' exposure to antibiotics while achieving clinical outcomes similar to those of 14-day schemes.
Methods: A randomized trial was performed. Adult patients developing eBSI with appropriate source control were assigned to 7 or 14 days of treatment, and followed 28 days after treatment cessation; treatments could be resumed whenever necessary.
Objectives: Endocarditis in patients with ascending aortic prosthetic graft (AAPG) is a life-threatening complication. The purpose of this study was to examine the clinical presentation and prognosis of patients with AAPG endocarditis included in a large prospective infectious endocarditis multicentre study.
Methods: From January 2008 to April 2015, 3200 consecutive patients with infectious endocarditis according to the modified Duke criteria, were prospectively included in the 'Spanish Collaboration on Endocarditis Registry (GAMES)' registry.
Article Synopsis
- The study aimed to evaluate the characteristics and outcomes of left-side endocarditis caused by gram-negative bacteria, revealing it as a rare condition impacting significantly ill patients.
- Among 961 endocarditis cases studied, only 24 (2.5%) were linked to gram-negative bacteria, with Escherichia coli and Pseudomonas aeruginosa being the most common pathogens, often affecting native valves in patients with pre-existing health issues.
- Complications such as renal failure, central nervous system involvement, and high mortality rates (41%) were noted, and while aminoglycosides were commonly used, they did not improve patient outcomes.
In order to analyze the clinical and therapeutic features of chronic hepatosplenic abscesses, and to define the diagnostic yield of new molecular techniques, we describe seven cases, four hepatic and three splenic, of this uncommon complication of Brucellosis. Onset of symptoms in all cases was insidious and the diagnostic delay considerable. Abdominal CT scan showed large, poorly defined lesions, with heterogeneous attenuation and thick central calcifications surrounded by hypointense areas.
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