Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes.

Background: Uveal melanoma is a poor prognosis cancer. Ergolide, a sesquiterpene lactone isolated from , exerts anti-cancer properties. The objective of this study was to evaluate whether ergolide reduced metastatic uveal melanoma (MUM) cell survival/viability and ; and to understand the molecular mechanism of ergolide action.