Saline irrigated catheter ablation for pulmonary vein isolation in pigs: an experimental model.

Focal AF is amenable to radical cure by RF ablation within the PV. The primary purpose of this study was to compare lesion characteristics for irrigated versus standard ablation using three power settings for PV isolation in pigs. Secondary analyses were the comparisons of ablation time and temperature characteristics, and evaluation of short-term safety in the pig model.

Angiotensin receptor blocker as adjunctive therapy for rhythm control in atrial fibrillation: results of the irbesartan-amiodarone trial.

Atrial fibrillation (AF) is a common arrhythmia associated with increased risk of stroke and mortality. The early appearance of electrical remodeling is followed by structural remodeling of the atrial tissue. Direct current cardioversion of persistent AF is the most effective treatment for the restoration of sinus rhythm, but it is hampered by a high percentage of recurrences.