Nutritional status and masticatory function of the indigenous compared with non-indigenous people of Nayarit, Mexico.

Objective: The objective of this study was to compare the nutritional statuses and masticatory function of the non-indigenous and indigenous adult people of the state of Nayarit, Mexico.

Design: Forty-two indigenous (Cora or Huichol ethnic group) and 100 non-indigenous people, all adults with natural dentition, participated in this cross-sectional study. They performed a free-style masticatory test consisting five trials of chewing silicon pieces for 20 cycles.

The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn.

Nitric oxide donors are known to produce headache in healthy as well as migraine subjects, and to induce extracephalic cutaneous hypersensitivity in rodents. However, little is known on the effect of nitric oxide donors on cephalic cutaneous sensitivity. Combining behavioral, immunohistochemical, and in vivo electrophysiological approaches, this study investigated the effect of systemic administration of the nitric oxide donor, isosorbide dinitrate (ISDN), on cephalic and extracephalic cutaneous sensitivity and on neuronal activation within the medullary dorsal horn (MDH) in the rat.

Opioid Mechanism Involvement in the Synergism Produced by the Combination of Diclofenac and Caffeine in the Formalin Model.

Analgesics can be administered in combination with caffeine for improved analgesic effectiveness in a process known as synergism. The mechanisms by which these combinations produce synergism are not yet fully understood. The aim of this study was to analyze whether the administration of diclofenac combined with caffeine produced antinociceptive synergism and whether opioid mechanisms played a role in this event.