Publications by authors named "Jose Maria Aspa Cilleruelo"
In this retrospective study, chimeric antigen receptor T cells remained effective in patients with relapsed/refractory large B-cell lymphoma after prior exposure to bispecific antibodies (BsAbs) targeting different antigens. These results are relevant to clinical practice, particularly given the increasing use of BsAbs in earlier treatment lines.
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- Researchers studied COVID-19 effects on patients with blood cancers in Spain between February 2020 and October 2022, focusing on trends during the Omicron variant.
- They found that older patients and those with other health issues had a higher chance of severe illness, but overall severity and death rates dropped during the Omicron period, especially for vaccinated individuals.
- Even though the risk of dying from COVID-19 has lowered, patients in hospitals, especially older ones, still have a high risk, and more research is needed on treatments for these patients.
Jumping translocations are uncommon cytogenetic abnormalities in which a segment of a donor chromosome, often 1q, is transferred to two or more receptor chromosomes. We describe the case of a 64-year-old man with a history of acute myeloid leukemia associated with myelodysplastic syndrome, who presented with a relapse of the leukemia and, concomitantly, with the appearance of a jumping translocation involving chromosome 1q. The patient had a poor clinical course without the possibility of performing targeted treatment, and he died 5 months after relapse.
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