Publications by authors named "Jose Manuel Santacruz"
Objectives: We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with Alzheimer's disease (AD) and Lewy body dementia (LBD) over a 5-year follow-up.
Methods: This is a longitudinal analysis of a Norwegian cohort study entitled "The Dementia Study of Western Norway" (DemVest). We included 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed annually for 5 years.
Purpose: High blood pressure is a relevant risk factor for vascular damage, leading to development of depressive symptoms and dementia in older adults. Moreover, subjective memory complaints are recognized as an early marker of cognitive impairment. However, it has been established that subjective memory complaints could also be a reflection of depressive symptoms.
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- The study investigates how the initial symptoms of apathy or disinhibition in patients with behavioral variant frontotemporal dementia (bvFTD) relate to their neurocognitive decline over time.
- Researchers compared healthy individuals with bvFTD patients exhibiting one of the two symptoms to identify brain atrophy and cognitive differences linked to each presentation.
- Findings suggest that the first symptom can predict future cognitive impairments and may aid in early detection and treatment strategies for bvFTD.