Publications by authors named "Jose Manuel Sanchez-Manas"

Article Synopsis
  • Pancreatic cancer is deadly and often undetected until it's too late, mainly due to ineffective current diagnostic methods and treatments.
  • Extracellular vesicles have been identified as promising biomarkers that could help in the early diagnosis and monitoring of pancreatic cancer via non-invasive liquid biopsies.
  • This review discusses the various roles of extracellular vesicles in cancer progression and their potential as valuable tools for diagnosis, prognosis, and therapy specifically for pancreatic cancer.
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Pediatric Acute Myeloid Leukemia (AML) is a rare and heterogeneous disease characterized by a high prevalence of gene fusions as driver mutations. Despite the improvement of survival in the last years, about 50% of patients still experience a relapse. It is not possible to improve prognosis only with further intensification of chemotherapy, as come with a severe cost to the health of patients, often resulting in treatment-related death or long-term sequels.

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Pancreatic cancer (PC) continues to pose a major clinical challenge. There has been little improvement in patient survival over the past few decades, and it is projected to become the second leading cause of cancer mortality by 2030. The dismal 5-year survival rate of less than 10% after the diagnosis is attributable to the lack of early symptoms, the absence of specific biomarkers for an early diagnosis, and the inadequacy of available chemotherapies.

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