Deprotonation mechanism of new antihypertensive piperidinylmethylphenols: a combined experimental and theoretical study.

Four new antihypertensive piperidinylmethylphenol compounds were synthesized for their potential antihypertensive and antiarhythmic properties. The pKa values were determined experimentally, with the aid of the program SQUAD, by capillary zone electrophoresis (CZE) at T=298.15 K and 0.