Publications by authors named "Jose Manuel Gonzalez-Navajas"
Background: Treatment with non-selective beta-blockers (NSBB) has been associated with anti-inflammatory and anti-cancer effects in patients with cirrhosis. This study aims to analyze the impact of chronic NSBB treatment on immune activation and disease progression in stable outpatients with cirrhosis.
Methods: In this prospective follow-up of 150 patients with cirrhosis, 39 received treatment with NSBB.
Chronic liver inflammation is crucial in the pathogenesis of hepatocellular carcinoma (HCC). Activation of the inflammasome complex is a key inflammatory process that has been associated with different liver diseases, but its role in HCC development remains largely unexplored. Here we analyzed the impact of different inflammasome components, including absent in melanoma 2 (AIM2) and NOD-like receptor family pyrin domain containing 3 (NLRP3), in the development of diethylnitrosamine (DEN)-induced HCC in mice.
View Article and Find Full Text PDFThe use of norfloxacin either as primary or secondary prophylaxis of bacterial infections in advanced cirrhosis has improved patient's survival. This may be explained not only due to a significant decrease in the number of infections, but also because of a direct immunomodulatory effect. Selective intestinal decontamination with norfloxacin reduces translocation of either viable bacteria or bacteria-driven products from the intestinal lumen.
View Article and Find Full Text PDFArticle Synopsis
- Bacterial peritonitis is a serious complication in cirrhosis patients, where infections lead to renal dysfunction and increased mortality despite antibiotic treatment.
- In an experiment with cirrhotic rats, different treatments were tested: placebo, ceftriaxone (an antibiotic), anti-TNF-α mAb alone, and a combination of both.
- Results showed that while ceftriaxone improved survival somewhat, the best outcome came from combining it with anti-TNF-α mAb, significantly lowering mortality compared to placebo, suggesting that this combined approach warrants further research to potentially improve patient outcomes in humans.
Background: Bacterial translocation is a frequent event in cirrhosis leading to an increased inflammatory response. Splanchnic adrenergic system hyperactivation has been related with increased bacterial translocation. We aim at evaluating the interacting mechanism between hepatic norepinephrine and inflammation during liver damage in the presence of bacterial-DNA.
View Article and Find Full Text PDF