Prognostic F-FDG Radiomic Features in Advanced High-Grade Serous Ovarian Cancer.

High-grade serous ovarian cancer (HGSOC) is an aggressive disease with different clinical outcomes and poor prognosis. This could be due to tumor heterogeneity. The 18F-FDG PET radiomic parameters permit addressing tumor heterogeneity.

Soft Tissue Aneurysmal Bone Cyst in the Sartorius Muscle of a 13-Year-Old Boy Mimicking Myositis Ossificans: Case Report.

Introduction: A soft tissue aneurysmal bone cyst is an extremely rare tumor. The objective of the article is to present the clinical, radiological, and histopathological features of a very unusual neoplasm of soft tissues.

Case Report: A 13-year-old male patient presented a painful, mobile, and rapidly growing mass on the posteromedial aspect of his left knee.

Explaining deep reinforcement learning decisions in complex multiagent settings: towards enabling automation in air traffic flow management.

With the objective to enhance human performance and maximize engagement during the performance of tasks, we aim to advance automation for decision making in complex and large-scale multi-agent settings. Towards these goals, this paper presents a deep multi agent reinforcement learning method for resolving demand - capacity imbalances in real-world Air Traffic Management settings with thousands of agents. Agents comprising the system are able to jointly decide on the measures to be applied to resolve imbalances, while they provide explanations on their decisions: This information is rendered and explored via appropriate visual analytics tools.

Supporting Visual Exploration of Iterative Job Scheduling.

We consider the general problem known as job shop scheduling, in which multiple jobs consist of sequential operations that need to be executed or served by appropriate machines having limited capacities. For example, train journeys (jobs) consist of moves and stops (operations) to be served by rail tracks and stations (machines). A schedule is an assignment of the job operations to machines and times where and when they will be executed.

Failure of scintigraphy lymphatic mapping in endometrial cancer. Causes and solutions.

Aim: To evaluate the effect of technical problems and patient characteristics on sentinel lymph node (SLN) scintigraphic detection and mapping success in early stages of endometrial cancer (EC).

Methods: Patients with clinical early stage EC (IA-IB) underwent SLN mapping using technetium-99m-nanocolloid, between September 2011 and February 2020 were included. There were excluded cases with technical problems, 92 patients were included for the analysis of the diagnostic performance and the relation of mapping failure (pelvic unilateral or not detected SLN) with patient (age, body mass index, previous pelvic disease or surgery) and disease characteristics (histology, grade, myometrial invasion, lymphovascular space infiltration, tumor size, and lymphatic infiltration risk).

Low-Grade Versus High-Grade Glioma… That Is the Question. 18F-Fluorocholine PET in the Detection of Anaplastic Focus.

Gliomas are characterized by intratumoral histological heterogeneity, coexisting foci of low and high grade. First, in low-grade gliomas, neoangiogenesis has not yet developed and cellularity is low, so alterations on perfusion MRI may not be present. Second, a non-negligible number of high-grade gliomas show none, patchy, or weak contrast enhancement on MRI, so they can be misdiagnosed as low-grade glioma, preventing their correct management.

Analysis of Flight Variability: a Systematic Approach.

In movement data analysis, there exists a problem of comparing multiple trajectories of moving objects to common or distinct reference trajectories. We introduce a general conceptual framework for comparative analysis of trajectories and an analytical procedure, which consists of (1) finding corresponding points in pairs of trajectories, (2) computation of pairwise difference measures, and (3) interactive visual analysis of the distributions of the differences with respect to space, time, set of moving objects, trajectory structures, and spatio-temporal context. We propose a combination of visualisation, interaction, and data transformation techniques supporting the analysis and demonstrate the use of our approach for solving a challenging problem from the aviation domain.

Value of [18F]FDG-PET/CT and CA125, serum levels and kinetic parameters, in early detection of ovarian cancer recurrence: Influence of histological subtypes and tumor stages.

To assess the diagnostic accuracy of CA125, its kinetic values and positron emission tomography/computed tomography with 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG-PET/CT), in relation with tumor characteristics for suspected recurrence of ovarian cancer. To evaluate the performance of CA125-related parameters as a selection criteria to perform a [F]FDG-PET/CT.A retrospective analysis of 69 [F]FDG-PET/CT for suspected recurrence of ovarian cancer was performed.

Usefulness of CA125 and its kinetic parameters and positron emission tomography/computed tomography (PET/CT) with fluorodeoxyglucose ([F] FDG) in the detection of recurrent ovarian cancer.

Background And Objective: To assess the usefulness of cancer antigen 125 (CA125) serum levels and kinetic values, velocity (CA125vel) and doubling time (CA125dt), as well as fluorodeoxyglucose ([F]FDG) positron emission tomography/computed tomography (PET/CT), in the detection of ovarian cancer recurrence. To assess the optimal cut-off for CA125, CA125vel and CA125dt to detect relapse with [F]FDG-PET/CT.

Material And Methods: A retrospective analysis was performed of 59 [F]FDG-PET/CT (48 patients) for suspected recurrence of ovarian cancer.

Clustering Trajectories by Relevant Parts for Air Traffic Analysis.

Clustering of trajectories of moving objects by similarity is an important technique in movement analysis. Existing distance functions assess the similarity between trajectories based on properties of the trajectory points or segments. The properties may include the spatial positions, times, and thematic attributes.

Role of 99mTc-HYNIC-Tyr3-octreotide scintigraphy in neuroendocrine tumors based on localization of the primary tumor.

Background: The aim of our work was to determine the accuracy of 99mTc-HYNIC Tyr3 octreotide scintigraphy (TcOS) in detecting active disease in neuroendocrine tumors (NETs) based on embryological origin of the primary tumor (foregut, midgut or hindgut).

Methods: We analyzed retrospectively 45 studies (12 staging, 26 suspicion of recurrence, and 7 treatment response) belonging to 33 patients with histological confirmation of NETs. Whole body scan and a SPECT-CT were acquired 4 hours post-injection of 740 MBq of 99mTc-HYNIC Tyr3 octreotide.

Comparison of different predictive tools of axillary status in breast cancer with micrometastatic sentinel node.

Aim: To compare the performance of six different nomograms and one score in the prediction of non-sentinel lymph node status in a subset of women with breast cancer and micrometastatic sentinel nodes (SN).

Material And Methods: Twenty-five patients were included in the study. Five different nomograms not specifically designed for micrometastatic SN, one recently published nomogram specially developed for this type of patients and one score were analyzed, and the corresponding receiver operating characteristic curves were obtained.

Semi-quantitative lymph node assessment of (18)F-FDG PET/CT in locally advanced breast cancer: correlation with biological prognostic factors.

Purpose: The aim of this study was to analyse the correlation between dual-time-point (18)F-2-deoxy-2-fluoro-D-glucose (FDG) uptakes in lymph nodes assessed by positron emission tomography (PET)/CT and histopathological and immunohistochemical prognostic factors.

Methods: Seventy-five women with locally advanced breast cancer were prospectively evaluated. PET/CT was requested in the initial staging previous to adjuvant chemotherapy (multicentre study).

18F-FDG retention index and biologic prognostic parameters in breast cancer.

Aim: To analyze the correlation between [(18)F]-fluoro-2-deoxy-D-glucose (F-FDG) uptake assessed by positron emission tomography/computed tomography (PET/CT) in breast tumors and histopathologic and immunohistochemical prognostic factors.

Material And Methods: Sixty-eight women with breast cancer were prospectively evaluated. PET/CT was requested in the initial staging previous to neoadjuvant chemotherapy (multicentric study).

Impact of radioguided occult lesion localization on the correct excision of malignant breast lesions: effect of histology and tumor size.

Aim: To evaluate the impact of radioguided occult lesion localization (ROLL) in the correct location and excision of malignant breast lesions, and analyze if these results are affected by the histology and tumor size.

Materials And Methods: A total of 105 patients with occult breast lesions were studied. The mean age was 55 years.

[Radioguided breast surgery. Evolution of the use of minimal-invasive technologies and current situation].

The increase in the detection of occult lesions has led to the development of new localisation methods using radiopharmaceutical products. The use of these products allows us to perform a "thrifty" (less-aggressive) surgical excision and, to simultaneously carry out the biopsy of the sentinel node in cases of breast cancer. On making a search for the most up to date references on this particular topic, we found many articles on radioguided surgery by many leading international work groups.