Publications by authors named "Jose Manuel Busto-Leis"
Introduction: Dupilumab has recently been shown to be effective in children under 6 years of age with atopic dermatitis (AD). Nevertheless, real-life and long-term follow-up data are scarce. We aimed to assess the effectiveness, safety, and long-term outcomes of dupilumab in a daily-practice setting in this age group.
View Article and Find Full Text PDFReal-world Performance of a New Strategy for Off-Label Use of Guselkumab in Moderate to Severe Psoriasis: Super-Responder Patients as the Epitome of Efficacy and Optimisation.
Clin Drug Investig
July 2023
Background: Guselkumab is a drug used to treat moderate to severe plaque psoriasis. However, real-life clinical data on its off-label use are limited, especially regarding the optimal drug dosage regimen for different patient profiles.
Objective: The main objective of this real-world, single-centre, retrospective study was to identify the off-label guselkumab dosing regimen used in clinical practice.
Article Synopsis
- Human monkeypox cases have risen globally since May 2022; the study explores the use of topical cidofovir as a treatment for skin lesions associated with the virus.
- A prospective study involved 12 patients treated with topical cidofovir 1%, resulting in faster lesion resolution compared to those receiving only symptomatic treatment.
- While cidofovir treatment significantly improved outcomes, local side effects were common, and the study's lack of a placebo-controlled arm limits its clinical validation.