Prognosis after heart transplant in patients with hypertrophic and restrictive cardiomyopathy. A nationwide registry analysis.

Introduction And Objectives: Posttransplant outcomes among recipients with a diagnosis of hypertrophic cardiomyopathy (HCM) or restrictive cardiomyopathy (RCM) remain controversial.

Methods: Retrospective analysis of a nationwide registry of first-time recipients undergoing isolated heart transplant between 1984 and 2021. One-year and 5-year mortality in recipients with HCM and RCM were compared with those with dilated cardiomyopathy (DCM).

Spanish Heart Transplantation Registry. 27th Official Report of the Spanish Society of Cardiology Working Group on Heart Failure and Heart Transplantation (1984-2015).

Introduction And Objectives: The present article reports the characteristics and results of heart transplants in Spain since this therapeutic modality was first used in May 1984.

Methods: We describe the main features of recipients, donors, surgical procedures, and results of all heart transplants performed in Spain until December 31, 2015.

Results: A total of 299 cardiac transplants were performed in 2015, with the whole series comprising 7588 procedures.

Viral load, CMV-specific T-cell immune response and cytomegalovirus disease in solid organ transplant recipients at higher risk for cytomegalovirus infection during preemptive therapy.

Despite advances in prevention, cytomegalovirus (CMV) recurrence is an important challenge in high-risk organ recipients. The present study prospectively evaluates the impact of CMV-specific T-cell immune response and secondary prophylaxis on the risk of recurrence in a cohort of CMV high-risk organ recipients and whether it is possible to determine a safe standardized viral load value below which CMV disease is unlikely. Thirty-nine recipients were included.

Antibodies against heterogeneous nuclear ribonucleoprotein K in patients with cardiac allograft vasculopathy.

Background: Cardiac allograft vasculopathy (CAV) is the most serious long-term complication after cardiac transplantation. T-cell-mediated immune response has been implicated as the central mechanism for this form of graft rejection, but the role of humoral immunity is still controversial.

Methods: This study investigated whether human leukocyte antigen (HLA) and non-HLA antibodies are associated with CAV and if their presence can be used to identify patients at high risk of developing CAV.