Publications by authors named "Jose M Reales Aviles"

Article Synopsis
  • Older patients with advanced hormone receptor-positive/HER2-negative breast cancer benefit from combining CDK4/6 inhibitors with standard endocrine therapy, according to recent studies.
  • There is a higher risk of side effects from these inhibitors in older patients, leading to a trend of starting them on lower doses, although this practice lacks strong evidence.
  • The IMPORTANT-trial aims
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Background: Neuroplasticity-based approaches seem to offer promising ways of maintaining cognitive health in older adults and postponing the onset of cognitive decline symptoms. Although previous research suggests that training can produce transfer effects, this study was designed to overcome some limitations of previous studies by incorporating an active control group and the assessment of training expectations.

Objective: The main objectives of this study are (1) to evaluate the effects of a randomized computer-based intervention consisting of training older adults with nonaction video games on brain and cognitive functions that decline with age, including attention and spatial working memory, using behavioral measures and electrophysiological recordings (event-related potentials [ERPs]) just after training and after a 6-month no-contact period; (2) to explore whether motivation, engagement, or expectations might account for possible training-related improvements; and (3) to examine whether inflammatory mechanisms assessed with noninvasive measurement of C-reactive protein in saliva impair cognitive training-induced effects.

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Unlabelled: Artificial neural networks are sophisticated modelling and prediction tools capable of extracting complex, non-linear relationships between predictor (input) and predicted (output) variables. This study explores this capacity by modelling non-linearities in the hardiness-modulated burnout process with a neural network. Specifically, two multi-layer feed-forward artificial neural networks are concatenated in an attempt to model the composite non-linear burnout process.

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Several sources of interference may simultaneously affect the onset of the well-known "Stroop effect." Among them is the semantic component, which is reflected in the gradient or semantic effect. This effect consists of an increase in the amount of interference as the semantic distance between the word and the color concept decreases.

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In this study, we investigated the effect of aging on two implicit memory tasks, word-stem completion and category generation, and on explicit recognition. We compared the performance of young and older adults on these implicit memory tasks with those of explicit recognition. We expected better performance of young than older adults in the explicit memory task and similar priming in both implicit memory tasks.

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The study of touch has recently grown, due mainly to the extensive use of several types of actuators that stimulate several subsystems of touch. There is a widespread interest in applying these mechanisms to the study of the neurophysiological correlates of tactual perception. In this article, we present a new device (the tactile spinning wheel [TSW]) for delivering textured surfaces to the finger pad.

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Taking into account the studies about the measure of sensitivity in magnitude estimation tasks, we analyze the three most common measures used in this topic: Pearson's product-moment correlation between the logarithm of the stimulus and the logarithm of the response (R), the exponent of Stevens' power function (K), and the measure "M" proposed by Garriga-Trillo. Using a sample of participants greater than usual in psychophysical studies (180 participants), we designed an experiment with two sets of stimuli with different stimulus ranges. In each of these sets, we used two kinds of stimuli (line segments and squares).

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