Risk factors for Central Nervous System drug use among nursing students.

Objectives: to verify sociodemographic, academic and health risk factors for Central Nervous System drug use among nursing students.

Methods: a cross-sectional study with 199 public undergraduate students from Ceará, using Characterization Instrument, Antonovsky's Sense of Coherence Questionnaire, Beck Depression Inventory and Beck Anxiety Inventory. Fischer's exact test and Pearson's chi-square test were performed, verifying an association between variables.

Tunning CO Separation Performance of Ionic Liquids through Asymmetric Anions.

This work aims to explore the gas permeation performance of two newly-designed ionic liquids, [Cmim][CFBF] and [Cmim][CFSOC(CN)], in supported ionic liquid membranes (SILM) configuration, as another effort to provide an overall insight on the gas permeation performance of functionalized-ionic liquids with the [Cmim] cation. [Cmim][CFBF] and [Cmim][CFSOC(CN)] single gas separation performance towards CO, N, and CH at T = 293 K and T = 308 K were measured using the time-lag method. Assessing the CO permeation results, [Cmim][CFBF] showed an undermined value of 710 Barrer at 293.

Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers-Relevance to COVID-19.

Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry for the CRS in the presence and absence of the Arg guanidino group occupying position 2 of Ang II. These findings suggest that Tyr is preferred over His for bearing the negative charge and that the CRS is stabilized by the guanidino group.

Submandibular gland tripeptide FEG (Phe-Glu-Gly) and analogues: keys to structure determination.

This study examined the structure activity relationship of NH(3)-Phe-Glu-Gly-COO(-) (FEG), a potent inhibitor of intestinal anaphylaxis. The inhibition by FEG analogues of antigen-provoked contractions of isolated ileal segments obtained from ovalbumin-sensitized rats was determined and molecular modeling performed. A combination of aromaticity of the first residue, minimal extension of the carboxyl group on residue 2, and underivatized N and C termini were essential for biological activity.