Publications by authors named "Jose M Gallego-Sanchez"
Article Synopsis
- CCL2 is a chemokine that plays a role in brain inflammation and impacts lymphocyte entry into brain tissue, but the exact mechanisms are not well understood.
- This study investigates which cell type overproduces CCL2 during T-cell infiltration in the brain across various scenarios and species.
- Findings indicate that CCL2+ astrocytes are involved in T-cell infiltration, with direct contact between T-cells and perivascular astrocytes potentially facilitating lymphocyte movement out of blood vessels into brain tissue.
The immunological synapse between T cells and tumor cells is believed to be important for effective tumor clearance. However, the immunological synapse has never been imaged or analyzed in detail in human tissue. In this work, intercellular interactions between T cells and tumor cells were analyzed in detail in human glioblastoma.
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