Publications by authors named "Jose M F Silva"
New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Roberta Reis Soares José Marcio Fernandes da Silva Bianca Cecheto Carlos Camila Campos da Fonseca Laila Salomé Araújo de Souza Adilson David da Silva
Bioorg Med Chem Lett
June 2015
Article Synopsis
- - Malaria remains a significant global health issue, complicated by widespread drug resistance, necessitating the search for new antimalarial compounds.
- - This study tested 10 synthetic compounds derived from quinoline, assessing their effectiveness against both drug-sensitive and resistant strains of Plasmodium falciparum, while ensuring minimal cytotoxicity to human cell lines.
- - Among the tested compounds, the hydrazine derivative 1f showed promising antimalarial activity, with a high selectivity index and effectiveness in mice, making it a prime candidate for future research in malaria treatment.
The complete nucleotide sequence and genomic organization of Citrus Leprosis associated Virus, Cytoplasmatic type (CiLV-C).
Renata C Pascon João Paulo Kitajima Michèle C Breton Laura Assumpção Christian Greggio Giovana G C Silva Vitor H Silva José M F Silva Ana Cláudia Rasera da Silva
Virus Genes
June 2006
The Citrus leprosis disease (CiL) is associated to a virus (CiLV) transmitted by Brevipalpus spp. mites (Acari: Tenuipalpidae). CiL is endemic in Brazil and its recently spreading to Central America represents a threat to citrus industry in the USA.
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