The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells.

Most antimicrobial peptides have been shown to have antitumoral activity. Cecropin A, a linear 37-residue antimicrobial polypeptide produced by the cecropia moth, has exhibited cytotoxicity in various human cancer cell lines and inhibitory effects on tumor growth. In this study, we investigated the apoptosis induced by cecropin A in the promyelocytic cell line HL-60.

[Linguistic adaptation into Spanish and psychometric validation of the ID-Pain questionnaire for the screening of neuropathic pain].

Background And Objective: To achieve a linguistic adaptation and psychometric validation into Spanish of the ID-Pain questionnaire for the screening of differential diagnosis of pain with a neuropathic component.

Material And Method: Cross-sectional validation study carried out in 2 phases (cultural adaptation into Spanish language and validation study to test psychometric properties of the scale) in men and women > 18 years, with neuropathic (NP) and nociceptive (NNP) chronic pain for more than 6 months. Feasibility and reliability were explored.

No supernovae associated with two long-duration gamma-ray bursts.

It is now accepted that long-duration gamma-ray bursts (GRBs) are produced during the collapse of a massive star. The standard 'collapsar' model predicts that a broad-lined and luminous type Ic core-collapse supernova accompanies every long-duration GRB. This association has been confirmed in observations of several nearby GRBs.