Biofilm on total joint replacement materials can be reduced through electromagnetic induction heating using a portable device.

Background: Periprosthetic joint infection is a serious complication following joint replacement. The development of bacterial biofilms bestows antibiotic resistance and restricts treatment via implant retention surgery. Electromagnetic induction heating is a novel technique for antibacterial treatment of metallic surfaces that has demonstrated in-vitro efficacy.

Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing.

Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety.

Liver tissue remodeling following ablation with irreversible electroporation in a porcine model.

Irreversible electroporation (IRE) is a method of non-thermal focal tissue ablation characterized by irreversibly permeabilizing the cell membranes while preserving the extracellular matrix. This study aimed to investigate tissue remodeling after IRE in a porcine model, especially focusing on the extracellular matrix and hepatic stellate cells. IRE ablation was performed on 11 female pigs at 2,000 V/cm electric field strength using a versatile high-voltage generator and 3 cm diameter parallel-plate electrodes.

Real-Time Impedance Monitoring During Electroporation Processes in Vegetal Tissue Using a High-Performance Generator.

Classical application of electroporation is carried out by using fixed protocols that do not clearly assure the complete ablation of the desired tissue. Nowadays, new methods that pursue the control of the treatment by studying the change in impedance during the applied pulses as a function of the electric field are being developed. These types of control seek to carry out the treatment in the fastest way, decreasing undesired effects and treatment time while ensuring the proper tumour ablation.

A new single-instrument technique for parenchyma division and hemostasis in liver resection: a clinical feasibility study.

The objective of this study was to evaluate the clinical feasibility of a new technique for liver resection based on a radiofrequency-assisted (485 kHz) device that has shown high performance in the animal setting in both transection speed and blood loss per transection area. Eight patients with colorectal hepatic metastasis underwent 11 partial hepatectomies using the proposed technique for both parenchyma division and hemostasis. Main outcome measures were blood loss per transection area and transection speed.

Research and development of a new RF-assisted device for bloodless rapid transection of the liver: computational modeling and in vivo experiments.

Background: Efficient and safe transection of biological tissue in liver surgery is strongly dependent on the ability to address both parenchymal division and hemostasis simultaneously. In addition to the conventional clamp crushing or finger fracture methods other techniques based on radiofrequency (RF) currents have been extensively employed to reduce intraoperative blood loss. In this paper we present our broad research plan for a new RF-assisted device for bloodless, rapid resection of the liver.

Laparoscopic blood-saving liver resection using a new radiofrequency-assisted device: preliminary report of an in vivo study with pig liver.

Background: The aim of any device designed for liver resection is to allow blood saving and quick resections. This may be optimized using a minimally invasive approach. A radiofrequency-assisted device is described that combines a cooled blunt-tip electrode with a sharp blade on one side in an in vivo preliminary study using hand-assisted laparoscopy to perform partial hepatectomies.

Small ablation zones created previous to saline infusion result in enlargement of the coagulated area during perfusion RF ablation: an ex vivo experimental study.

One of the strategies for enlarging coagulation zone dimensions during RF ablation of liver tumours is to infuse saline solutions into the tissue during ablation. The aim of this study was to evaluate experimentally whether the creation of a small coagulation adjacent to a bipolar RF applicator and prior to perfused RF ablation would allow enlargement of the coagulation zone. Thirty bipolar RF ablations (group A, n = 15; group B, n = 15) were performed in excised bovine livers.

RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?

Background: Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown.

Improved perfusion system for bipolar radiofrequency ablation of liver: preliminary findings from a computer modeling study.

Current systems for radiofrequency ablation of liver tumors are unable to consistently treat tumors larger than 3 cm in diameter with a single electrode in a single application. One of the strategies for enlarging coagulation zone dimensions is to infuse saline solutions into the tissue through the active electrodes. Nevertheless, the uncontrolled and undirected diffusion of boiling saline into the tissue has been associated with irregular coagulation zones and severe complications, mainly due to reflux of saline along the electrode path.

Evolving technology in bipolar perfused radiofrequency ablation: assessment of efficacy, predictability and safety in a pig liver model.

Bipolar radiofrequency (RF) ablation, especially with perfusion of saline, has been shown to increase volume over monopolar conventional methods. The aims of this study are to study whether this method is linked to too flattened thermal lesions and premature rise of impedance and to elucidate some safety concerns. Eighteen RF ablations were performed using a 1.

Bipolar saline-enhanced electrode for radiofrequency ablation: results of experimental study of in vivo porcine liver.

Purpose: To evaluate whether a bipolar saline-enhanced radiofrequency (RF) ablation system embedded in one needle is able to consistently produce homogeneous and predictable areas of coagulation necrosis with or without the Pringle maneuver of vascular inflow occlusion.

Materials And Methods: RF ablation (480 kHz) of the liver was performed in 24 healthy pigs by means of laparotomy: group A (n = 5), 4-cm distance between electrodes 1 and 2; group B (n = 7), 4-cm distance and the Pringle maneuver; group C (n = 5), 2-cm distance; and group D (n = 7), 2-cm distance with the Pringle maneuver. Twenty percent NaCl solution was infused continuously at a rate of 100 mL/h via each electrode during the procedure.

Large hepatic ablation with bipolar saline-enhanced radiofrequency: an experimental study in in vivo porcine liver with a novel approach.

Summary Background Data: Radiofrequency ablation (RFA) is a relatively new technology for the local destruction of liver tumors. Development of recent devices has enabled the creation of larger lesions. Nevertheless, treating liver tumors larger than 2.