Publications by Jose M Batista

Publications by authors named "Jose M Batista"

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Immunoprecipitation of RNA-DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in the control of surface antigen expression needed for immune evasion by antigenic variation.

Mark J Girasol Emma M Briggs Catarina A Marques José M Batista Dario Beraldi

Nucleic Acids Res

November 2023

Article Synopsis

* Research on the African trypanosome, a unique single-cell eukaryotic parasite, identified 602 potential proteins that interact with RNA-DNA hybrids, revealing both shared and unique functions compared to mammals.
* Certain factors, like helicases and RAD51 paralogues, are crucial for maintaining RNA-DNA hybrid levels and DNA damage repair in T. brucei, influencing its ability to evade the host's immune response.

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Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

Loic Fort José Miguel Batista Peter A Thomason Heather J Spence Jamie A Whitelaw

Nat Cell Biol

October 2018

Actin-based protrusions are reinforced through positive feedback, but it is unclear what restricts their size, or limits positive signals when they retract or split. We identify an evolutionarily conserved regulator of actin-based protrusion: CYRI (CYFIP-related Rac interactor) also known as Fam49 (family of unknown function 49). CYRI binds activated Rac1 via a domain of unknown function (DUF1394) shared with CYFIP, defining DUF1394 as a Rac1-binding module.