Publications by authors named "Jose Luis Sierra"

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries. However, most studies in Peru have focused on Lima, the capital city, without knowing the dynamics of the spread of the variant in other departments.

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Learning Objects represent a widespread approach to structuring instructional materials in a large variety of educational contexts. The main aim of this work consists of analyzing the process of generating reusable learning objects followed by , a tool that can be used to retrieve data from multiple medical knowledge sources and reconfigure such sources in diverse multimedia-based structures and organizations. From these organizations, is able to generate learning objects that can be adapted to various instructional healthcare scenarios with several types of user profiles and distinct learning requirements.

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Article Synopsis
  • The study investigates whether plasma Lyso-Gb3 levels can help differentiate between multiple sclerosis (MS) and Anderson-Fabry disease (FD) in patients already diagnosed with MS, particularly focusing on a Spanish cohort.
  • Researchers analyzed α-galactosidase A enzyme activity and GLA gene variants in 154 MS patients, with the aim of identifying any correlation with the presence of FD.
  • Findings show that all subjects had Lyso-Gb3 levels below the critical threshold of 3.5 ng/mL, suggesting that these patients do not have FD, thus supporting the use of Lyso-Gb3 concentration as a reliable diagnostic tool.
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Intermediate-salinity environments are distributed around the world. Here, we present a snapshot characterization of two Peruvian thalassohaline environments at high altitude, Maras and Acos, which provide an excellent opportunity to increase our understanding of these ecosystems. The main goal of this study was to assess the structure and functional diversity of the communities of microorganisms in an intermediate-salinity environment, and we used a metagenomic shotgun approach for this analysis.

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In this paper, we describe a new approach to generating standardized e-Learning content from existing medical collections. The core of this approach is a tool called Clavy, which makes it possible to retrieve information items from medical collections, to transform these items into meaningful learning units, and to export them in the form of standardized e-Learning packages. In addition to describing the approach, we assess its feasibility by applying it to the generation of IMS Content Packages from MedPix, an online database of medical cases in the domain of radiology.

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