Identification of -Oxide-Containing Aromatic Heterocycles as Pharmacophores for Rumen Fermentation Modifiers.

Different strategies have been used to mitigate greenhouse gas emissions from domesticated ruminants, including the removal of protozoa (defaunation). The objective of the present work was to analyze the potential of different -oxide-containing aromatic heterocycles with known antiprotozoal activity as rumen-gas-abating agents. Nineteen pure compounds, belonging to seven different -oxide chemotypes from our chemo-library were studied together with monensin in an in vitro rumen simulation assay.

Anaerobic metabolism of the agro-pesticide nitroxinil by bovine ruminal fluid.

Metabolism of three different agro-pesticides widely used in Uruguay, the insecticides imidacloprid and thiamethoxam and the antiparasite nitroxinil, by bovine ruminal fluid, as supply of anaerobic microorganims, was studied. Complete ruminal fluid was incubated with each of the agrochemicals in different conditions, varying time, nutrients, and nitroethane supplementation as methanogenesis modificator. Only biotransformation was detected for nitroxinil in some of the studied variables.