Publications by authors named "Jose Luis Jimenez Fuentes"
Article Synopsis
- Immune-based TB diagnostic tests currently have low sensitivity in children and struggle to differentiate between latent TB infection (LTBI) and active TB disease.
- The study analyzed 17 biomarkers in plasma from children with confirmed TB, LTBI, and non-TB infections, finding significant biomarkers like IFN-γ and IL-2 that effectively predicted TB status.
- The IFN-γ/MCP-1 ratio emerged as the most promising combination for distinguishing between MTB-infected and non-infected children, suggesting a need for further research to improve pediatric TB diagnosis.
Reliable and accurate quantification of cell-associated HIV DNA (CA HIV DNA) is critical for early infant diagnosis, clinical management of patients under therapy, and to inform new therapeutics efficacy. The present study assessed the variability of CA HIV DNA quantification obtained from various assays and the value of using reference materials to help harmonize the measurements. Using a common set of reagents, our multicenter collaborative study highlights significant variability of CA HIV DNA quantification and lower limit of quantification across assays.
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